EHSRC Investigator Detail
| Jerrold P. Weiss, M.D. | |
| Professor of Internal Medicine and Microbiology |
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| Email: jerrold-weiss@uiowa.edu | |
| Phone: (319) 335-4268 | |
| EHSRC Role(s): | Member, Inflammation and Innate Immunity Research Cluster |
Work in Dr. Weiss' laboratory is focused in two main areas: 1) the structural and biochemical mechanisms of host recognition of Gram-negative bacterial endotoxins and the coupling of endotoxin recognition to the induction of inflammation, bacterial killing and clearance and detoxification of endotoxin and other bacterial remnants; and 2) cellular and extracellular mechanisms of host defense against Gram-positive bacteria and the role and regulation of D-alanylation of bacterial envelope teichoic acids in bacterial resistance to innate host defenses and in bacterial persistence.
Recent Publications
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Gioannini TL, Teghanemt A, Zhang D, Prohinar P, Levis EN, Munford RS, Weiss JP. Endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase. J Biol Chem. 2007 Mar 16;282(11):7877-84. Epub 2007 Jan 16.
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Prohinar P, Re F, Widstrom R, Zhang D, Teghanemt A, Weiss JP, Gioannini TL. Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain. J Biol Chem. 2007 Jan 12;282(2):1010-7. Epub 2006 Nov 22.
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Koprivnjak T, Mlakar V, Swanson L, Fournier B, Peschel A, Weiss JP. Cation-induced transcriptional regulation of the dlt operon of Staphylococcus aureus. J Bacteriol. 2006 May;188(10):3622-30.
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Hunt CL, Nauseef WM, Weiss JP. Effect of D-alanylation of (lipo)teichoic acids of Staphylococcus aureus on host secretory phospholipase A2 action before and after phagocytosis by human neutrophils. J Immunol. 2006 Apr 15;176(8):4987-94.
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Post DM, Zhang D, Weiss JP, Gibson BW. Stable isotope metabolic labeling of Neisseria meningitidis lipooligosaccharide. J Endotoxin Res. 2006;12(2):93-8.