Environmental Health Sciences Research Center

Peter S. Thorne, Ph.D.
Professor and Head, Occupational & Environmental Health
Email: peter-thorne@uiowa.edu
Phone: (319) 335-4216
EHSRC Role(s):	Center Director
	Director, Pulmonary Toxicology Facility
	Co-Leader, Nanotoxicology Research Core
	Member, Environmental Lung Disease Research Cluster
	Member, Inflammation and Innate Immunity Research Cluster

Dr. Thorne is engaged in studies of environmental risk factors for asthma, inflammatory lung diseases, endotoxin- and glucan-induced immunomodulation, and novel methodology for exposure assessment and modelling. He is internationally recognized for his discoveries in the exacerbation of asthma associated with domestic and occupational exposures to bioaerosols, especially endotoxin. He teaches graduate level courses on environmental health, human toxicology, and research methods in biological agents. He serves on a variety of editorial and review boards for scientific journals, government agencies, and academic institutions.

In addition to directing the EHSRC and the Pulmonary Toxicology Facility, Dr. Thorne is co-investigator on an EPA-funded study of “Impacts of Manufactured Nanomaterials on Human Health and the Environment”. He is an investigator on a large number of grants and subcontracts with colleagues at the University of Iowa as well as USC, Columbia, National Jewish, UNC and Johns-Hopkins. He is also a co-investigator on the Iowa Superfund Basic Research Program under the direction of Dr. Larry Robertson. Dr. Thorne is the PI of a large epidemiology project on children’s environmental health (Research Project 6), Leader of the Toxicology Core, and Leader of the Research Translation Core within the proposed Iowa superfund basic research program.

Hađina S, Weiss JP, McCray PB Jr., Kulhankova K, Thorne PS. MD-2-dependent pulmonary immune responses to inhaled lipoligosaccharide: effect of acylation state of LOS. Am J Respir Cell Mol Biol 38(6):647-654, 2008. PMCID: PMC2396245.

Grassian VH, O'Shaughnessy PT, Adamcakova-Dodd A, Pettibone JM, Thorne PS. Titanium dioxide nanoparticles: Grassian et al. respond. Environ Health Perspect 116(4):A152-3, 2008.

Pettibone JM, Adamcakova-Dodd A, Thorne PS, O’Shaughnessy PT, Weydert JA and Grassian VH. Inflammatory response of mice following inhalation exposure to iron and copper nanoparticles. Nanotoxicology, 2(4):189-204, 2008.

Trompette A, Divanovic S, Visintin A, Blanchard C, Hegde RS, Madan R, Thorne PS, Wills-Karp M, Gioannini TL, Weiss JP, Karp CL. Functional mimicry between the major house dust mite allergen, Der p 2, and the TLR4 complex protein, MD-2. Nature 457(7229):585-8, 2009. doi:10.1038/nature07548. PMC2843411

Thorne PS, Cohn R, Mav D, Arbes Jr. SJ, Zeldin DC. Predictors of endotoxin levels in U.S. Housing. Environ Health Perspect, 117(5):763-71, 2009. PMC2685839. doi:10.1289/ehp.11759. [Online Oct 16 2008].

Thorne PS, Ansley A, Perry SS. Concentrations of bioaerosols, odors and hydrogen sulfide inside and downwind from two types of swine livestock operations. J Occup Environ Hyg 6(4):211-220, 2009. doi: 110.1080/ 15459620802729184 [Online Jan 2009].

Kulhankova K, George CLS, Kline JN, Snyder JM, Darling M, Field EH, Thorne PS. Early Life Co-Administration of Cockroach Allergen and Endotoxin Augments Pulmonary and Systemic Responses. Clin Exp Allergy 39(7):1069-79, 2009. doi:10.111/j.1365-2222.2009.03254.x

Murthy S, Adamcakova-Dodd A, Perry SS, Tephly LA, Keller RM, Metwali N, Meyerholz DK, Wang Y, Glogauer M, Thorne PS, Carter AB. Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 297(5):L846-55, 2009. PMC2777495

Noss I, Wouters IM, Bezemer G, Metwali N, Sander I, Raulf-Heimsoth M, Heederik DJJ, Thorne PS and Doekes G. β-(1,3)-glucan exposure assessment by passive airborne dust sampling and new sensitive immunoassays. Appl Environ Microbiol 76(4):1158-1167, 2010. Epub 2009 Dec 28. PMC2820944

Semple S, Devakumar D, Fullerton DG, Thorne PS, Metwali N, Costello A, Gordon SB, Manadhar DS, and Ayres JG. Airborne endotoxin concentrations in homes burning biomass fuel. Environ Health Perspect, 118(7):988-991, 2010. PMC2920920

Manzel LJ, Shi L, O’Shaughnessy PT, Thorne PS and Look DC. Cigarette smoke inhibition of the NF-kB-dependent response to bacteria in the airway. Am J Respir Cell Mol Biol. 44(2):155-65, 2011.

Noss I, Doekes G, Sander I, Heederik DJJ, Thorne PS, Wouters IM. Passive airborne dust sampling with the electrostatic dustfall collector: optimization of storage and extraction procedures for endotoxin and glucan measurement. Ann Occup Hyg, 54(6):651-658, 2010.

Thorne PS, Perry SS, Saito R, O’Shaughnessy PT, Mehaffy J, Metwali N, Keefe T, Donham KJ and Reynolds SJ. Evaluation of the Limulus amebocyte lysate and recombinant Factor C assays for assessment of airborne endotoxin. Appl. Environ. Microbiol. 76(15):4988-4995, 2010. PMC2916455

Hu X, Adamcakova-Dodd A, Lehmler HJ, Hu D, Korwel I, Hornbuckle KC,, Thorne PS. Time course of congener uptake and elimination in rats after inhalation of airborne polychlorinated biphenyl(PCB) mixtures. Environ. Sci. Technol., 44(17):6893-6900, 2010.

Stebounova L, Adamcakova-Dodd A, Kim JS, Park H, O’Shaughnessy PT, Grassian VH, Thorne PS. Nanosilver induces minimal lung toxicity or inflammation in a subacute murine inhalation model. Part Fibre Toxicol. 25;8(1):5, 2011. PMC3040588

ENVIRONMENTAL HEALTH SCIENCES RESEARCH CENTER A National Institute of Environmental Health Sciences Center of Excellence

ENVIRONMENTAL HEALTH SCIENCES RESEARCH CENTER
A National Institute of Environmental Health Sciences Center of Excellence