EHSRC Investigator Detail
| Douglas M. Shasby, M.D. | |
| Professor of Internal Medicine |
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| Email: michael-shasby@uiowa.edu | |
| Phone: (319) 356-4418 | |
| EHSRC Role(s): | Member, Inflammation and Innate Immunity Research Cluster |
Dr. Shasby's research examines the acute inflammatory response and how it affects lung endothelial and epithelial surfaces. His current work focuses on cell adhesion molecules and how their function is altered by inflammatory agonists such as histamine. His clinical interests are in critical care, bronchoscopy and asthma.
Recent Publications
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Humlicek AL, Manzel LJ, Chin CL, Shi L, Excoffon KJ, Winter MC, Shasby DM, Look DC. Paracellular permeability restricts airway epithelial responses to selectively allow activation by mediators at the basolateral surface. J Immunol. 2007 May 15;178(10):6395-403.
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Shasby DM. Cell-cell adhesion in lung endothelium. Am J Physiol Lung Cell Mol Physiol. 2007 Mar;292(3):L593-607. Epub 2006 Nov 3.
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Winter MC, Shasby SS, Ries DR, Shasby DM. PAR2 activation interrupts E-cadherin adhesion and compromises the airway epithelial barrier: protective effect of beta-agonists. Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L628-35. Epub 2006 May 19.
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Winter MC, Shasby SS, Ries DR, Shasby DM. Histamine selectively interrupts VE-cadherin adhesion independently of capacitive calcium entry. Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L816-23. Epub 2004 Jun 25.
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Shasby DM, McCray P. Sepsis and innate immunity. Am J Respir Crit Care Med. 2004 Jan 15;169(2):144-5.