ENVIRONMENTAL HEALTH SCIENCES RESEARCH CENTER
A National Institute of Environmental Health Sciences Center of Excellence

Dr. Salem's research interests are primarily focused on self-assembling systems, the rational design of novel drug and gene delivery systems and on the development of vaccines that stimulate potent antigen-specific immune responses. 

Recent Publications

1. Intra J, Salem AK. Characterization of the transgene expression generated by branched and linear polyethylenimine (PEI)-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo. Journal of Controlled Release doi:10.1016/j.jconrel.2008.04.014 2008.
   
   
2. Pearce ME, Mai HQ, Lee N, Larsen SC, Salem AK. Silicalite nanoparticles that promote transgene expression. Nanotechnology (19) 175103, 2008.
   
   
3. Intra J, Glasgow JM, Mai HQ, Salem AK. Pulsatile release of biomolecules from polydimethylsiloxane (PDMS) chips with hydrolytically degradable seals. Journal of Controlled Release (127) 280-287, 2008.
   
   
4. Clapper JD, Pearce ME, Guymon CA, Salem AK. Biotinylated biodegradable nanotemplated hydrogel networks for cell interactive applications. Biomacromolecules (9) 1188-1194, 2008.
   
   
5. Krishnamachari Y, Pearce ME, Salem AK. Self-assembly of cell-microparticle hybrids. Advanced Materials. 20 (5): 989-993, 2008.
   
   
6. Zhang XQ, Intra J, Salem AK. Comparative study of poly (lactic-co-glycolic acid)-poly ethyleneimine-plasmid DNA microparticles prepared using double emulsion methods. Journal of Microencapsulation. (25) 1-13, 2008.
   
   
7. Abbas AO, Donovan MD, Salem AK. Formulating PLGA particles for plasmid DNA delivery. Journal of Pharmaceutical Sciences.  97(7):2448-61, 2008.
   
   
8. Salem AK. Frontiers in Drug Design and Discovery. Volume 3. Journal of Medicinal Chemistry. 51(4):1073 2008.
   
   
9. Graham JB, Pearce ME, Salem AK. Multifunctional, Spherical & Anisotropic Metal and Metal Oxide Nanomaterials in Medical Diagnosis and Therapy. Invited Chapter in "Nanomaterials for the Life Sciences – Volume 3". Wiley-VCH. Edited by Challa Kumar. 2008.
   
   
10. Krishnamachari Y, Salem AK. Nano-Bio Polymers and Composites. Invited chapter in "Nano-and Biocomposites". Taylor & Francis/CRC Press. Edited by Lau and Hussain. 2008.