Environmental Health Sciences Research Center

EHSRC Investigator Detail

COEC

Larry W. Robertson, Ph.D.
Professor of Occupational & Environmental Health
Email: larry-robertson@uiowa.edu
Phone: (319) 335-4554
Robertson Home Page
Iowa Superfund Basic Research Program
The University of Iowa Interdisciplinary Graduate Program in Human Toxicology
EHSRC Role(s):	Director, Pilot Grant Program
	Co-Director, Oxidative Stress and Metabolism Research Cluster

Dr. Robertson's primary area of research is the mechanism(s) of toxicity of polyhalogenated aromatic hydrocarbons. Members of this class include the polychlorinated biphenyls (PCBs), dibenzodioxins, dibenzofurans and various pesticides. Dr. Robertson's research on these important environmental pollutants include studies of their effects on gene regulation, their metabolism to electrophilic species and their binding to nucleophiles, including amino acids, nucleotides and DNA.

Recent Publications

Sadeghi-Aliabadi H, Chan K, Lehmler HJ, Robertson LW, O'Brien PJ. Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes. Chem Biol Interact. 2007 May 1;167(3):184-92. Epub 2007 Feb 23.
Luthe G, Swenson DC, Robertson LW. Influence of fluoro-substitution on the planarity of 4-chlorobiphenyl (PCB 3). Acta Crystallogr B. 2007 Apr;63(Pt 2):319-27. Epub 2007 Mar 16.
Kania-Korwel I, Shaikh NS, Hornbuckle KC, Robertson LW, Lehmler HJ. Enantioselective disposition of PCB 136 (2,2',3,3',6,6'-hexachlorobiphenyl) in C57BL/6 mice after oral and intraperitoneal administration. Chirality. 2007 Jan;19(1):56-66.
Liu Y, Apak TI, Lehmler HJ, Robertson LW, Duffel MW. Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol. 2006 Nov;19(11):1420-5.
Ptak A, Ludewig G, Kapiszewska M, Magnowska Z, Lehmler HJ, Robertson LW, Gregoraszczuk EL. Induction of cytochromes P450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary. Toxicol Lett. 2006 Oct 25;166(3):200-11. Epub 2006 Jul 14.
Strathmann J, Schwarz M, Tharappel JC, Glauert HP, Spear BT, Robertson LW, Appel KE, Buchmann A. PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors. Toxicol Sci. 2006 Sep;93(1):34-40. Epub 2006 Jun 16.
Bender RP, Lehmler HJ, Robertson LW, Ludewig G, Osheroff N. Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. Biochemistry. 2006 Aug 22;45(33):10140-52.
Kunz S, Schwarz M, Schilling B, Papke O, Lehmler HJ, Robertson LW, Schrenk D, Schmitz HJ. Tumor promoting potency of PCBs 28 and 101 in rat liver. Toxicol Lett. 2006 Jul 1;164(2):133-43. Epub 2006 Jan 19.
Kania-Korwel I, Garrison AW, Avants JK, Hornbuckle KC, Robertson LW, Sulkowski WW, Lehmler HJ. Distribution of chiral PCBs in selected tissues in the laboratory rat. Environ Sci Technol. 2006 Jun 15;40(12):3704-10.
Luthe G, Leonards PE, Reijerink GS, Liu H, Johansen JE, Robertson LW. Monofluorinated analogues of polybrominated diphenyl ethers as analytical standards: synthesis, NMR, and GC-MS characterization and molecular orbital studies. Environ Sci Technol. 2006 May 1;40(9):3023-9.
Wang LQ, Lehmler HJ, Robertson LW, James MO. Polychlorobiphenylols are selective inhibitors of human phenol sulfotransferase 1A1 with 4-nitrophenol as a substrate. Chem Biol Interact. 2006 Feb 25;159(3):235-46.