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EHSRC Investigator Detail

Larry W. Robertson, Ph.D.

Professor of Occupational & Environmental Health

Email: larry-robertson@uiowa.edu
Phone: (319) 335-4554
Robertson Home Page
Iowa Superfund Basic Research Program

The University of Iowa Interdisciplinary Graduate Program in Human Toxicology
EHSRC Role(s): Director, Pilot Grant Program
  Director, Oxidative Stress and Metabolism Research Cluster

Dr. Robertson's primary area of research is the mechanism(s) of toxicity of polyhalogenated aromatic hydrocarbons. Members of this class include the polychlorinated biphenyls (PCBs), dibenzodioxins, dibenzofurans and various pesticides. Dr. Robertson's research on these important environmental pollutants include studies of their effects on gene regulation, their metabolism to electrophilic species and their binding to nucleophiles, including amino acids, nucleotides and DNA.

Recent Publications

  1. Johannes Kloesener, Thomas Peters, Andrea Dodd, Lynn Teesch, P.S. Thorne, Larry W. Robertson, Gregor Luthe, Innovative application of Fluoro-tagging to trace airborne particulate and gas phase  PBDE exposures.  Chemical Research in Toxicology. In Press.
  2. Orarat Wangpradit, Santhana Mariappan, Lynn Teesch, Karin Norstrom, Michael Duffel,  Larry W. Robertson, Gregor Luthe, Novel biotransformation by prostaglandin H synthase generates highly toxic electrophilic metabolites. Chemical Research in Toxicology. In Press.
  3. Isaac Pessah, Hans-Joachim Lehmler, Larry W. Robertson, Claudio Perez, Elaine Cabrales, Diptiman Bose, Wei Feng, Enantiomeric Specificity of (-)-2,2’,3,3’,6,6’-Hexachlorobiphenyl ((-) - PCB 136) Towards Ryanodine Receptor Types 1 and 2. Chemical Research in Toxicology. In Press.
  4. Yang Song, Garry Buettner, Sean Parkin, Brett Wagner, Larry W. Robertson, Hans-Joachim Lehmler. Chlorination Increases the Persistence of Semiquinone Free Radicals Derived from Polychlorinated Biphenyl Hydroquinones and Quinones. Journal of Organic Chemistry 73, 8296-8304 (2008).
  5. Job C. Tharappel, Hans-Joachim Lehmler, Cidambi Srinivasan, Larry W. Robertson, Brett T. Spear, and Howard P. Glauert. Effect of Antioxidant Phytochemicals on the Hepatic Tumor Promoting Activity of 3,3',4,4'-Tetrachlorobiphenyl (PCB-77). Food and Chemical Toxicology 46, 3467–3474 (2008).
  6. Venkatesha A Venkatasubbaiah, Sujatha Venkataraman, Ehab H Sarsour, Amanda L Kalen, Garry R Buettner, Larry W Robertson, Hans-Joachim Lehmler, Prabhat C Goswami.  Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in non-malignant human breast epithelial cells. Free Radical Biology & Medicine 45, 1094–1102 (2008).
  7. Howard P. Glauert, Job C. Tharappel, Subhashis Banerjee, Nelson L. S. Chan, Izabela Kania-Korwel, Hans-Joachim Lehmler, Eun Y. Lee, Larry W. Robertson, and Brett T. Spear. Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-KB in mice. Toxicol. Appl. Pharmacol. 232, 302-308 (2008) doi:10.1016/j.taap.2008.06.013.
  8. Izabela Kania-Korwel, Wei Xie, Keri C. Hornbuckle, Larry W. Robertson, Hans-Joachim Lehmler, Enantiomeric Enrichment of 2,2’,3,3’,6,6’-Hexachlorobiphenyl (PCB 136) in Mice After Induction of CYP Enzymes. Arch. Environ. Contam. Toxicol. 55, 510-517 (2008), DOI 10.1007/s00244-007-9111-4.
  9. Sanjay Telu, Sean Parkin, Larry W. Robertson and Hans-Joachim Lehmler, 1,3,5-Trichloro-2-methoxybenzene. Acta Crystallographica Section E Structure Reports Online. Acta Cryst. E64, o424 (2008).
  10. Gregor Luthe, Regine Garcia Boy, James Jacobus, Brian Smith, Asif Rahaman, Larry W. Robertson, and Gabriele Ludewig. Xenobiotic Geometry and Media pH determine Cytotoxicity through Solubility. Chem. Res. Toxicol. 21, 1017–1027 (2008).
  11. J. Klösener, D. C. Swenson, L. W. Robertson and G. Luthe. Effects of fluoro substitution on 4-bromodiphenyl ether (PBDE 3). Acta Cryst. B64, 108–119 (2008).
  12. James C. Sacco, Hans-Joachim Lehmler, Larry W. Robertson, Wenjun Li, and Margaret O. James. Glucuronidation of polychlorinated biphenylols and UDPGA concentration in channel catfish liver and intestine. Drug Metabolism and Disposition 36, 623–630 (2008).
  13. Divinia N. Stemm, Job C. Tharappel, Hans-Joachim Lehmler, Cidambi Srinivasan, J. Steven Morris, Vickie L. Spate, Larry W. Robertson, Brett T. Spear and Howard P. Glauert.  Effect of Dietary Selenium on the Promotion of Hepatocarcinogenesis by 3,3’,4,4’-Tetrachlorobiphenyl and 2,2’,4,4’,5,5’-Hexachlorobiphenyl. Exp. Biol. Med. 233, 366–376 (2008).
  14. I. Kania-Korwel, K.C. Hornbuckle, L.W. Robertson, and H.-J. Lehmler. Influence of dietary fat on the enantioselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in female mice.  Food and Chemical Toxicology 46, 637–644 (2008).
  15. I. Kania-Korwel, K. Hornbuckle, L. Robertson, H.-J. Lehmler, Dose-Dependent Enantiomeric Enrichment of 2,2',3,3',6,6'-Hexachlorobiphenyl in Female Mice. Environ Toxicol Chem. 27, 299-305 (2008).
  16. Larry W. Robertson, Isabelle Berberian, Tim Borges, Li-Chuan Chen, Ching K. Chow, Howard P. Glauert, Johannes G. Filser and Helmut Thomas. Suppression of peroxisomal enzyme activities and cytochrome P-4504A isozyme expression by congeneric polybrominated and polychlorinated biphenyls.  PPAR Research, vol. 2007, Article ID 15481, 5 pages, 2007. doi:10.1155/2007/15481.
  17. Markus Zettner, Susanne Flor, Gabriele Ludewig, Jörg Wagner, Larry W. Robertson, Leane Lehmann, Quinoid Metabolites of 4-monochlorobiphenyl (PCB3) Induce Gene Mutations in Cultured Chinese Hamster V79 Cells. Toxicological Sciences 100, 88–98 (2007).
  18. Rodica Petruta Bunaciu, Job C. Tharappel, Hans-Joachim Lehmler, Izabela Korwel, Larry W. Robertson, Cidambi Srinivasan, Brett T. Spear, and Howard P. Glauert. The Effect of Dietary Glycine on the Hepatic Tumor Promoting Activity of Polychlorinated Biphenyls (PCBs) in Rats. Toxicology 239, 147–155 (2007).
  19. H. Sadeghi-aliabadi, K. Chan, H.-J. Lehmler, L.W. Robertson, P.J. O’Brien, Molecular cytotoxic mechanisms of catecholic Polychlorinated Biphenyl metabolites in isolated rat hepatocytes, Chemico-Biological Interactions 167, 184-192 (2007).
  20. G. Luthe, D. C. Swenson and L.W. Robertson, Influence of fluoro-substitution on the planarity of 4-chlorobiphenyl (PCB 3), Acta Crystallographica, Section B: Structural Science 63, 319-327 (2007).
  21. Gabriele Ludewig, Harald Esch and Larry W. Robertson, Polyhalogenierte Bi- und Terphenyle, Chapter 20, In: Dunkelberg, H., Gebel, T., Hartwig, A. (Editors) Handbuch der Lebensmitteltoxikologie, Wiley-VCH Weinheim, pages 1031-1094 (2007). 
  22. I. Kania-Korwel, N.S. Shaikh, K.C. Hornbuckle, L.W. Robertson, H.-J. Lehmler.  Enantioselective disposition of PCB 136 (2,2’,3,3’,6,6’-hexachlorobiphenyl) in C57BL/6 mice after oral and intraperitoneal administration. Chirality 19, 56-66 (2007).  
  23. Leane Lehmann, Harald L. Esch, Patricia A. Kirby, Larry W. Robertson, Gabriele Ludewig.  4-Monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats.  Carcinogenesis 28, 471–478 (2007).

  Environmental Health Sciences Research Center, The University of Iowa, 100 Oakdale Campus, #178 IREH, Iowa City, IA 52242

Tel: (319) 335-4756 / Fax: (319) 335-4225 / E-mail: nancy-newkirk@uiowa.edu