Pulmonary Toxicology Facility
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The goal of the Pulmonary Toxicology Facility Core (PTF, formerly the Inhalation Toxicology Facility) is to provide the facilities and expertise for EHSRC investigators to enhance the productivity and quality of their pulmonary toxicology research and to assist them in exploring new investigative areas in asthma, pulmonary biology, inhalation toxicology, or aerosol science. In addition, investigators from NIEHS-funded Environmental Health Centers are supported with expertise and assays for evaluation of exposures to asthma triggers. This facility provides assistance for testing hypotheses regarding the: |
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Specific Aims
Specific aims for the Pulmonary Toxicology Facility include the following:
- Provide consultation and services to Center investigators interested in using animal models for environmental health research.
- Perform acute, subacute, and subchronic inhalation exposures (and sham exposures) to groups of rodents with rigidly controlled gases, vapors, aerosols, or combined exposures using nose-only or whole-body exposure systems.
- Perform measurements of animal biomarkers of exposure and biomarkers of effect to identify early biologic responses, low dose functional changes, and susceptibility or host resistance factors.
- Provide measurements of sensitive physiologic endpoints such as forced oscillation airway resistance, lung and tissue elastance with or without methacholine challenge.
- Develop innovative animal models for investigating or identifying potential causal agents of disease or for developing novel inhalation therapies including development and maintenance of transgenic and knockout mice.
- Develop improved aerosol and bioaerosol sampling and analysis methodology using new analysis systems.
- Develop novel aerosol generation and quantitation methodology for the study of inhaled nanoparticulates.
- Facilitate pre-doctoral and post-doctoral training.
Members
Peter S. Thorne, PhD
Patrick O’Shaughnessy, PhD
Nervana Metwali, PhD
Andrea Adamčaková-Dodd, PhD
Richard Keller, B.S.E., M.S.
Kevin M. Kelly, PhD
Suzana Hađina, DVM, PhD
Director
Co-Director
Biochemist
Toxicologist
Environmental Engineer
Biostatistician
Veterinarian
Occupational & Environmental Health
Occupational & Environmental Health
Occupational & Environmental Health
Occupational & Environmental Health
Occupational & Environmental Health
Occupational & Environmental Health
Occupational & Environmental Health