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EHSRC Pilot Grant Program - Funded Applications

1996 - 2000

 

  1996      

Investigator(s):   
Thomas B. Casale, Professor, Internal Medicine; Victoria M. Steelman, Ph.D. Candidate, College of Nursing; Rita Frantz, Associate Professor, College of Nursing
Project Title:    
Prevalence and Risk Factors of Adverse Reactions to Products Containing Natural Rubber Among Nursing Staff
Year Funded: 
1996
Amount Received: 
$15,000
Publications:
  1. Victoria Steelman.  Prevalence and Risk Factors of Adverse Reactions to  Natural Rubber, Latex Among Nursing Personnel.  Ph.D. Thesis, 1997.

Investigator(s):   
Alan B. Moy, Assistant Professor, Internal Medicine
Project Title:    
Development of an In Vitro Human Airway Model to Study LPS-Induced Airway Dysfunction
Year Funded: 
1996
Amount Received: 
$15,000
Grant Awards:
  1. Regulation of Lung Edema Based on a Tensegrity Paradigm.  American Lung Association-Clinical Investigator Award.  $105,000
  2. Regulation of Lung Edema Based on a Tensegrity Paradigm.  NIH  1RO1HL60629.  $1,866,631.
  3. Role of Endothelial Integrins on Inflammatory Edema.  NIH 1RO1GM59734.  $1,525,964.

Investigator(s):   
Raymond J. Hohl, Associate Professor, Internal Medicine; David M. Gustin, Post-doctoral Fellow, Internal Medicine
Project Title:    
Abnormalities of RAS Expression in Noninvasive Bladder Carcinoma
Year Funded: 
1996
Amount Received: 
$15,000
Publications:
  1. Hohl RJ, Lewis RA, Cermak DM, Wiemer DF.  Stereochemistry-dependent inhibition of RAS fainesylation by farnesyl phosphonic acids.  Lipids 1998; 33(1):39-46.
  2. Lewis KA, Hohl RJ.  Modulation of RAS expression in human malignant cells by dietary supplements.  Nutrition 1997; 13(10):921-923.
Grant Awards:
  1. 5M01RR000059-350859. R. Hohl, PI.  High Dose Lovastatin for Treatment of RAS Oncogene Associated Malignancies, 1996.  $15,000

Investigator(s):   
Vicki H. Grassian, Assistant Professor, Department of Chemistry
Project Title:    
Reactions of Atmospheric Gases on Model Tropospheric Aerosols
Year Funded: 
1996
Amount Received: 
$15,000
Publications:
  1. Goodman AL, Miller TM, Grassian VH.  Heterogeneous reactions of nitrogen dioxide on A12O3 and NaCl particles.  J Vac Sci and Technology A 1998; 16:2585-2590.
  2. Miller TM, Gassian VH.  Heterogeneous reactions of NO2 on mineral oxide particles:  spectroscopic evidence for oxide-coordinated and water-solvated surface nitrate.  Geophysical Research Letters 1998; 25:3835-3838.
  3. Todd Miller.  Heterogeneous reactions of nitrogen oxides on metal oxide particles.  Ph.D. Thesis, 1998.
  4. Underwood, G. M., Miller, T. M. and Grassian, V.H. Transmission FT-IR and Knudsen Cell Study of the Heterogeneous Reactivity of Gaseous Nitrogen Dioxide on Mineral Oxide Particles Journal of Physical Chemistry A 1999, 103, 6184-6190..  
  5. Song, C. H.; Phadnis, M.; Carmichael, G. R.; Underwood, G. M.; Miller, T. M.; Balster, E. and Grassian, V. H.  Modelling Heterogenous Reactions in Air Pollution Models  a Chapter in Air Pollution VII, pages 685-695, WIT Press South Hampton , Boston (1999). (Invited)
  6. Goodman, A.L.; Underwood, G. M. and Grassian, V. H. A Spectroscopic Investigation of the Heterogeneous Reaction 2NO2 + H2O(a)   HONO(g) + HNO3(a) on Hydrated Silica Particles:  Characterization of Gas-Phase and Adsorbed Products Journal of Physical Chemistry A  1999, 103, 7217-7223.
  7. Underwood, G. M.; Li, P.; Usher, C.; and Grassian V.H. Determining Accurate Kinetic Parameters of Potentially Important Heterogeneous Atmospheric Reactions on Solid Particle Surfaces Using a Knudsen Cell Reactor Journal of Physical Chemistry A 2000, 104, 819-829.
  8. Goodman, A. L.; Underwood, and Grassian V.H.  Laboratory Study of the Heterogeneous Reactions of HNO3 on CaCO3 Particles J. Geophys. Res.- Atmospheres 2000, 104, 29,053-29,064.
  9. Al-Abadleh; H. A. and V. H. Grassian  Heterogeneous Reaction of NO2 on Hexane Soot:  A Knudsen Cell and FT-IR Study Journal of Physical Chemistry - A. 2000, 104, 11926-11933.
  10. Li, P.; Perreau, K. A.; Covingtion, E.; Carmichael, G. C.; Grassian, V. H. Heterogeneous Reactions of Volatile Organic Compounds on Oxide Particles of the Most Abundant Elements Present in the Earth's Crust: Surface Reactions of Acetaldehyde, Acetone and Propionaldehyde on SiO2, Al2O3, Fe2O3, TiO2 and CaO J. Geophys. Res.- Atmospheres, 2001 ,106 , 5517-5529.
  11. Underwood, G. M.; Song, C. H.; Phadnis, M.; Carmichael; G. C. and Grassian V.H.  Heterogeneous Reactions of NO2 and HNO3 on Mineral Oxides and Mineral Dust: A Combined Laboratory and Modeling Study J. Geophys. Res.- Atmospheres t 2001, 106, 18055 -18066  (Invited submission to a special issue on mineral dust).
  12. Grassian, V. H.  Heterogeneous Uptake and Reaction of Nitrogen Oxides and Volatile Organic Compounds on the Surface of Atmospheric Particles Including Oxide, Carbonate, Soot and Mineral Dust:  Implications for the Chemical Balance of the Troposphere. International Reviews of Physical Chemistry 2001, 20, 467-548. (Invited Review Article)
  13. Goodman, A. L.; Li, P.; Usher, C.R.. and Grassian, V. H.  Heterogeneous Reaction of Sulfur Dioxide on Aluminum and Magnesium Oxide Particles Journal of Physical Chemistry A 2001, 105, 6109 - 6120.
  14. Goodman, A. L.; Bernard, E.B. and Grassian, V. H.  A Spectroscopic Study of Nitric Acid and Water Adsorption on Oxide Particles: Enhanced Nitric Acid Uptake Kinetics in the Presence of Adsorbed Water   Journal of Physical Chemistry A 2001, 105, 6443 - 6457.
  15. Underwood, G. M., Li, P., Al-Abadleh, H. and Grassian V.H.  A Knudsen Cell Study of the Heterogeneous Reactivity of Nitric Acid on Oxide and Mineral Dust Particles Journal of Physical Chemistry A 2001,  105, 6609-6620.
  16. Li, P., Al-Abadleh, H. A. and Grassian, V. H. Measuring Heterogeneous Uptake on Solid Particle Surfaces with a Knudsen Cell Reactor:  Complications Due to Surface Saturation and Gas Diffusion Journal of Physical Chemistry A 2002,106, 1210-1219.
  17. Grassian, V. H. Chemical Reactions of Nitrogen Oxides on the Surface of Oxide, Carbonate, Soot and Mineral Dust Particles:  Implications for the Chemical Balance of the Troposphere. Invited Feature Article in Journal of Physical Chemistry A 2002, 106, 860-877.
  18. Usher, C. R., Al-Hosney, H., Carlos-Cuellar, S., and Grassian, V. H. , Heterogenous Uptake and Oxidation of SO2 on Mineral Dust J. Geo. Res. - Atmospheres 2002 (DOI 10.1029/2002JD002051).
  19. Michel, A. E.; Usher, C. R. and Grassian, V. H.  Heterogeneous and Catalytic Uptake of Ozone on Mineral Oxides and Dust:  A Knudsen Cell Investigation Geophys. Res. Letts. 2002 29, 10-1 to 10-4. (DOI 10.1029/2001GL014304).
  20. Preszler Prince, A., J. Wade, J., Grassian, V. H.,  Kleiber,P. and Young, M. A., Heterogeneous Reactions of Soot Aerosols with Nitrogen Dioxide and Nitric Acid Studied in an Atmospheric Chamber Atmos. Env. 2002 , 36, 5729-5740.
  21. Al-Abadleh, H. A. and Grassian, V. H., FT-IR Study of Water Adsorption on Aluminum Oxide Surfaces Langmuir 2003, 19, 341-347.
  22. Krueger, B. J., Grassian, V. H., Laskin, A. and Cowin, J. P., The Transformation of Solid Atmospheric Particles into Liquid Droplets through Heterogeneous Chemistry:  Laboratory Insights into the Processing of Calcium Containing Mineral Dust Aerosol in the Troposphere Geophys. Res. Letts. 2003 30, 48-1 to 48-4. (DOI 10.1029/2002GL016563).
  23. Carlos-Cuellar, S, Christensen, A.P., Burrichter, C., Li, P. and Grassian, V. H. Heterogeneous Uptake Kinetics of VOCs on Oxide Surfaces Using a Knudsen Cell Reactor:  Adsorption of Acetic Acid, Formaldehyde and Methanol on a-Al2O3, SiO2 and a-Fe2O3 J. Phys. Chem. A. 2003, 107, 4250-4261.
  24. Michel, A. E., Usher, C. R. and Grassian, V. H. Reactive Uptake of Ozone on Mineral Oxides and Mineral Dusts Atmos. Env. 2003, 37, 3201-3211.
  25. Krueger, B. J., Grassian, V. H., Iedema, M. J., Cowin, J. P.  and Laskin, A.  Probing Heterogeneous Chemistry of Individual Atmospheric Particles Using Scanning Electron Microscopy Analytical Chemistry 2003, 75, 5170-5179.
  26. Usher, C. R., Michel, A. E., Stec, D. and Grassian, V. H., Laboratory Studies of Ozone Uptake on Processed Mineral Dust Atmos. Env. 2003, 37, 5337.
  27. Al-Abadleh, H.A. Krueger, B.J., Ross, J. L. and Grassian, V. H., Phase Transitions in Calcium Nitrate Thin Films Chem. Comm., 2003, 2796- 2797.
  28. Al-Abadleh, H. A. and V. H. Grassian Oxide Surfaces as Environmental Interfaces Surface Science Reports 2003, 52, 63-161 (Invited Review Article).
  29. Usher, C. R. , Michel, A. E. and Grassian, V. H. Reactions on Mineral Dust, Chemical Reviews 2003, 103, 4883 - 4940 (Invited Review Article). 
  30. Al-Hosney, H. A. and Grassian, V. H.  Carbonic Acid:  An Important Intermediate in the Surface Chemistry of Calcium Carbonate J. Am. Chem. Soc. 2004, 126, 8068-8069.
  31. Krueger, B. J., Grassian, V. H. ,  Laskin, A. and J. Cowin. Heterogeneous Chemistry of Individual Mineral Dust Particles from Different Dust Source Regions:  The Importance of Particle Mineralogy  Atmospheric Environment 2004, 38, 6253-6261.
  32. Johnson, E. R. and Grassian, V. H. Environmental Catalysis of the Earth's Atmosphere: Heterogeneous Reactions on Mineral Dust Aerosol Environmental Catalysis, Ed. Vicki H. Grassian, CRC Publishing, Boca Raton, FL, 2005.
  33. Al-Abadleh, H.A., Al-Hosney, H. A. and Grassian, V. H. Oxide and Carbonate Surfaces as Environmental Interfaces: The Importance of Water in Surface Composition and Surface Reactivity J. Molecular Catalysis A 2005, 228, 47-54.
  34. Al-Hosney, H. A., Grassian, V. H. Water, Sulfur Dioxide and Nitric Acid Adsorption on Calcium Carbonate:  A Transmission and ATR-FTIR Study. Physical Chemistry Chemical Physics 2005, 7, 1266 – 1276.
  35. Laskin, A., Wietsma, T. W., Krueger, B. J., Grassian, V. H., Heterogeneous Chemistry of Individual Mineral Dust Particles with Nitric Acid.  A Combined CCSEM/EDX, ESEM and ICP-MS Study. J. Geophys. Res. 2005, 110, D10208,doi:10.1029/2004JD005206, 1-15.
  36. Baltrusaitas, J. and Grassian, V. H. Surface Reactions of Carbon Dioxide at the Adsorbed Water-Iron Oxide Interface J. Phys. Chem. B 2005, 109, 12227-12230.
  37. Johnson, E. R., Sciegienka, J. Carlos-Cuellar, S and Grassian, V. H. Heterogeneous Uptake of Gaseous Nitric Acid on Dolomite (CaMg(CO3)2) and Calcite (CaCO3) Particles:  A Knudsen Cell Study Using Multiple, Single and Fractional Particle Layers Journal of Physical Chemistry A, 2005, 109, 6901-6911.
  38. Al-Hosney, H. A., Carlos-Cuellar, S.; Baltrusaitis, J. and Grassian, V.H. Heterogeneous Uptake and Reactivity of Formic Acid on Calcium Carbonate Particles: A Knudsen Cell Reactor, FTIR and SEM Study Physical Chemistry Chemical Physics, 2005, 7, 3587 - 3595.  (Cover Art)
Grant Awards:
  1. A combined experimental and computational study of troposphere chemistry on aerosol surfaces.  Department of Energy.  $473,000.
  2. Postdoctoral opportunities in laboratory and modeling studies of environmental and atmospheric chemistry at the University of Iowa.  Camille and Henry Dreyfus postdoctoral program in Environmental Chemistry.  $96,000.
  3. Thermal and photo-assisted reactions on metal oxide particles.  National Science Foundation.  $275,000.
  4. Chemical Reactions of Environmental and Atmospheric Relevance on the Surface of Oxide Particles.  (2000 - 2005)  National Science Foundation. $629,000. (PI:  Vicki H. Grassian; note this includes a two-year creativity extension for $275,000 )
  5. Chemical Reactions of Environmental and Atmospheric Relevance on Carbonate Surfaces. $612,500. (2005-2009).National Science Foundation(PI: Vicki H. Grassian)
  6. The role of heterogeneous chemistry in the photochemical oxidant cycle: a combined laboratory and modeling study. Dept. of Energy. $640,824.

Investigator(s):   
Joel N. Kline, Assistant Professor, Division of Pulmonary Medicine
Project Title:    
Effects of CpG Oligonucleotides on a Murine Model of Eosinophilic Airways Inflammation
Year Funded: 
1996
Amount Received: 
$15,000
Publications:
  1. Kline JN, Waldschmidt TA, Businga TR, Lemish JE, Weinstock JV, Thorne PS, Krieg AM.    Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma.  J Immunol 1998; 160:2555-2559.
  2. Ferguson JS, Kline JN.  Tuberculosis:  Emerging Role of DNA Vaccines.  Medscape, In Press, 2004.
  3. Kline JN, Krieg AM, Waldschmidt TJ, Ballas ZK, Jain V, Businga TR.    CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma.
    J Allergy Clin Immunol. 104(6):1258-64, 1999.
  4. Kline JN.  Effects of CpG DNA on Th1/Th2 Balance in Asthma.  In:  Immunology of Bacterial CpG-DNA, Current Topics in Microbiology and Immunology, H. Wagner Editor, Springer-Verlag.  In Press, 2004.
  5. Krieg AM, Kline JN. Immune effects and therapeutic applications of CpG motifs in bacterial DNA. Immunopharmacology. 48(3): 303-5, Jul 2000.
  6. Kline JN. Effects of CpG DNA on Th1/Th2 balance in asthma. Current Topics in Microbiology and Immunology. 247: 211-25, 2000.
  7. Kline JN, Kitagaki K, Businga TR, Jain VV. Treatment of established asthma in a murine model using CpG oligodeoxynucleotides. American Journal of Physiology. Lung Cellular and Molecular Physiology. 283(1): L170-9, Jul 2002.
  8. Jain VV, Kitagaki K, Businga T, Hussain I, George C, O'shaughnessy P, Kline JN. CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma. The Journal of Allergy and Clinical Immunology. 110(6): 867-72, Dec 2002.
  9. Hussain I, Kline JN. CpG oligodeoxynucleotides in asthma. Current Opinion in Investigational Drugs (london, England : 2000). 2(7): 914-8, Jul 2001.
  10. Hussain I, Jain VV, Kitagaki K, Businga TR, O'Shaughnessy P, Kline JN. Modulation of murine allergic rhinosinusitis by CpG oligodeoxynucleotides. The Laryngoscope. 112(10): 1819-26, Oct 2002.
  11. Kitagaki K, Jain VV, Businga TR, Hussain I, Kline JN. Immunomodulatory effects of CpG oligodeoxynucleotides on established th2 responses. Clinical and Diagnostic Laboratory Immunology. 9(6): 1260-9, Nov 2002.
  12. Hussain I, Kline JN. CpG oligodeoxynucleotides: a novel therapeutic approach for atopic disorders. Current Drug Targets. Inflammation and Allergy. 2(3): 199-205, Sep 2003.
  13. Jain VV, Kitagaki K, Kline JN. CpG DNA and immunotherapy of allergic airway diseases. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology.. 33(10): 1330-5, Oct 2003.
  14. Jain VV, Businga TR, Kitagaki K, George CL, O'Shaughnessy PT, Kline JN. Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure. American Journal of Physiology. Lung Cellular and Molecular Physiology. 285(5): L1137-46, Nov 2003.
Grant Awards:
  1. Modulation of eosinophilic lung inflammation by CpG  DNA.  NIH, R01 HL 59324.  $350,000.
  2. Effect of CpG DNA on asthma inflammatory response.American Lung Association Research Grant.  $50,000.
  3. CpG Motifs in Plasmid DNA as Barrier to Gene Transfer.  NIH 5M01RR000059-391044.       

 

1997

Investigator(s):   
William A. Groves, Assistant Professor, Preventive Medicine and Environmental Health
Project Title:    
Field Analysis of Perchloroethylene in Breath Using a Surface-Acoustic-Wave Microsensor-Based Instrument
Year Funded: 
1997
Amount Received: 
$15,000
Publications:
  1. Groves WA, Achutan C.  Laboratory and Field Evaluation of a Surface Acoustic Wave Microsensor Array for Measuring Perchloroethylene in Breath.  In Press, 2004.

Investigator(s):   
Gunnar Gudmundsson, Fellow Associate, Pulmonary and Critical Care Medicine; Gary Hunninghake, Professor, Internal Medicine
Project Title:    
Genetic Determinants of Hypersensitivity Pneumonitis
Year Funded: 
1997
Amount Received: 
$15,000
Publications:
  1. Gudmundsson G, Hunninghake G.  Interferon-gamma is necessary for the expression of hypersensitivity pneumonitis.  J Clin Invest, 1997; 99:2386-2390.
  2. Gudmundsson G, Monick MM, Hunninghake GW.  Interleukin-12 modulates expression of hypersensitivity pneumonitis.  J Immunol 1998; 161:991-999.
  3. Gudmundsson G, Monick M, Hunninghake GW.  Viral infection modulates expression of hypersensitivity pneumonitis.  J Immunol, 1999; 162:7397-7401.
  4. Gudmundsson G, Hunninghake GW.  Respiratory epithelial cells release interleukin-8 in response to a thermophilic bacteria that causes hypersensitivity pneumonitis.   Exp Lung Res, 1999; 25:217-228.
  5. Gunnar Gudmundsson. Cytokines in Hypersensitivity Pneumonitis. University of Iceland. Ph.D Thesis, 2000.
Grant Awards:
  1. The Role of DNA in Hypersensitivity Pneumonitis. Icelandic Research Council.  $10,000.
  2. The Role of DNA and IL-12 in Hypersensitivity Pneumonitis. University of Iceland Research Fund.  $12,900.
  3. The Role of DNA and IL-12 in Hypersensitivity Pneumonitis. National University Hospital of Iceland.  $7,200.

Investigator(s):   
Joseph M. Reinhardt, Adjunct Assistant Professor, Radiology; Eric A. Hoffman, Professor, Radiology and Biomedical Engineering; Stephen S. Raab, Assistant Professor, Pathology
Project Title:    
Accurate Measurement of Intra-Thoracic Airways via X-Ray CT
Year Funded: 
1997
Amount Received: 
$15,000
Publications:
  1. Reinhardt JM, Hoffman EA.  Quantitative Pulmonary Imaging:  Spatial and Temporal Considerations in High Resolution CT.   Academic Radiology 1998; 5(8):539-546.
  2. Reinhardt JM, D’Souza ND, Hoffman EA.  Accurate Measurement of Intra-Thoracic Airways.  IEEE Trans on Medical Imaging 1997; 165(6):820-827.
  3. Reinhardt JM, Raab SA, D’Souza ND, Hoffman EA.  Intra-thoracic airway measurement:  Ex-vivo validation.  Proc SPIE Conf on Medial Imaging 1997; 3033:69-80.
  4. Saba OI, Hoffman EA, Reinhardt JM.  Maximizing quantitative accuracy of lung airway lumen and wall measures obtained from X-ray CT imaging.  J Appl Physiol. 95(3):1063-75, 2003.
Grant Awards:
  1. CAREER: Program in Pulmonary Imaging. National Science Foundation $375,000.

Investigator(s):   
Mark A. Young, Assistant Professor, Chemistry; Peter S. Thorne, Associate Professor, Preventive Medicine and Environmental Health
Project Title:    
Real-Time Chemical Analysis of Single Bioaerosol Particles
Year Funded: 
1997
Amount Received: 
$15,000

 

1998

Investigator(s):   
Andrea J. DeLeo, Fellow, Department of Neurology, Movement Disorder Section
Project Title:    
Impact of Environmental Exposures on the Incidence and Natural History of Parkinson’s Disease in Iowa Residents
Year Funded: 
1998
Amount Received: 
$15,000

Investigator(s):   
Gary Hunninghake, Professor, Internal Medicine; Gunnar Gudmundsson, Fellow Associate, Internal Medicine
Project Title:    
Effects of Endotoxin on the Expression of Hypersensitivity Pneumonitis
Year Funded: 
1998
Amount Received: 
$15,000
Publications:
  1. Gudmundsson G, Hunninghake GW. Interferon-gamma is necessary for the expression of hypersensitivity pneumonitis.  J Clin Invest, 99:2389-2390, 1997.
  2. Gudmundsson G, Monick MM, Hunninghake GW, IL-12 modulates expression of hypersensitivity pneumonitis. J. Immunol, 161:991-999, 1998.
  3. Gudmundsson G, Hunninghake GW. Interleukin-10 modulates the severity of hypersensitivity pneumonitis in mice. Am J Respir Cell Mol Biol, 19:912-8, 1998.
  4. Gudmundsson G, Monick MM, Hunninghake GW. Viral infection modulates expression of hypersensitivity pneumonitis. J. Immunol, 162:7397-7401, 1999.
  5. Gudmundsson G, Hunninghake GW. Respiratory epithelial cells release interleukin-8 in response to a thermophilic bacteria that causes hypersensitivity pneumonitis.  Exp Lung Res, 25:217-228, 1999.
  6. Gudmundsson G. Cytokines in hypersensitivity pneumonitis. (PhD Thesis) University of Iceland, 2000.
  7. Butler NS, Monick MM, Yarovinsky TO, Powers LS, Hunninghake GW.  Altered IL-4 mRNA stability correlates with Th1/Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. J. Immunol. 169:3700-3709, 2002.
Grant Awards:
  1. 5M01RR000059-380804.  G. Hunninghake, PI.  Determinants of Disease Activity and Prognosis for Interstitial Lung Disease, 1999.
  2. 1P01ES009607-010003.  G. Hunninghake, PI.  Role of RSV Infection and Endotoxin In Airway Inflammation, 1999.
  3. 5P01ES009607-02.  G. Hunninghake, PI.  Airway Disease in Children from Rural Communities, 2000.

Investigator(s):   
Patrick T. O’Shaughnessy, Assistant Professor, Preventive Medicine and Environmental Health
Project Title:    
Exposure Chamber Characterization and Automation
Year Funded: 
1998
Amount Received: 
$15,000
Publications:
  1. Stacy Hearne.  Evaluation of grain-dust generating techniques.  M. S. Thesis, 2000.
Grant Awards:
  1. 1K01OH000176-01.  P. O’Shaughnessy, PI.  Ventilation Control to Reduce Airborne Contaminants, 1999.

Investigator(s):   
William A. Groves, Assistant Professor, Preventive Medicine and Environmental Health
Project Title:    
Field Evaluation of a Dermal Pesticide Exposure Assessment Algorithm
Year Funded: 
1998
Amount Received: 
$15,000
Publications:
  1. Groves WA, Reynolds SJ, Dosemeci M, Prince JR, Alvanja MC.  Validation of a Dermal Pesticide Exposure Assessment Algorithm Using Video Imaging—Feasibility Survey and Pilot Study.  In Press, 2004.
Grant Awards:
  1. 1K01OH000177-01A1. W. Groves, PI.   System for Measuring Workplace Protection Factors, 1999.

Investigator(s):   
Jeffrey A. Kern, Associate Professor, Internal Medicine
Project Title:    
Genetic Determinants of Lung Cancer; A Feasibility Study
Year Funded: 
1998
Amount Received: 
$15,000

Investigator(s):   
Virend K. Somers, Associate Professor, Cardiology and Internal Medicine
Project Title:    
Acute Effects of Passive Smoke Exposure on Endothelium-Dependent Vasodilation in Healthy Non-Smokers
Year Funded: 
1998
Amount Received: 
$15,000
Publications:
  1. Kato M, Roberts-Thomson P, Phillips BG, Narkiewicz, K, Haynes WG, Pesek CA and Somers VK.  The Effects of Short-Term Passive Smoke Exposure on Endothelium-dependent and Independent Vasodilation.    J Hypertension.  In Press, 2004.
Grant Awards:
  1. 1R01HL061560-01, V. Somers, PI.  Mechanisms Mediating Cardiovascular Responses to Smoking, 1999.

 

1999

Investigator(s):   
Caroline Duchaine, Postdoctoral Fellow; Peter S. Thorne, Professor, Preventive Medicine and Environmental Health
Project Title:    
Quantification of Airborne Bacteria by Direct Most Probable Number-Polymerase Chain Reaction
Year Funded: 
1999
Amount Received: 
$20,000
Grant Awards:
  1. Health Hazards from Microbial Growth in Metal Working Fluids.  UAW-Daimler Chrysler National Training Center  $199,350.
  2. Quantification of airborne bacteria by direct MPN-PCR.  Medical Research Council of Canada.
  3. Quantification PCR for detection of airborne bacteria.  Fonds de Research en Santé du Quebec.

Investigator(s):   
Patrick O'Shaughnessy, Assistant Professor, Preventive Medicine and Environmental Health, and Civil and Environmental Engineering; Keri C. Hornbuckle, Assistant Professor, Civil and Environmental Engineering
Project Title:    
Use of an Environmental Chamber for Investigating Gas-Particle Partitioning of PotentiallyToxic Organic Compounds
Year Funded: 
1999
Amount Received: 
$20,000
Publications:
  1. Aaron Peck.  Gas-particle partitioning of toxic organic compounds.  Ph.D. Thesis, Expected 2004.

Investigator(s):   
Josef B. Simeonsson, Assistant Professor, Chemistry; Michael Cohen, Professor, Pathology
Project Title:    
A New Analytical Technique for the Direct Measurement and Imaging of Trace Selenium in Prostate Tissue Slices
Year Funded: 
1999
Amount Received: 
$20,000

Investigator(s):   
Peter S. Thorne, Professor; Erik R. Svendsen, Ph.D. Candidate; Stephen J. Reynolds, Associate Professor; Patrick T. O'Shaughnessy, Assistant Professor; Preventive Medicine and Environmental Health
Project Title:    
Factors Influencing Surface Sampling of House Dust Mite Allergens from Worn Carpets
Year Funded: 
1999
Amount Received: 
$20,000
Publications:
  1. Eric Svendsen.  The Relationship of Household Exposures to Childhood Asthma.  Ph. D. Thesis, 2002.
Grant Awards:
  1. NIEHS:Exposure Intervention in a Rural Pediatric Asthma Cohort: Louisa Environmental Intervention Project (PI: PS Thorne), $1,499,785.  9/30/2001 – 7/31/2006.

Investigator(s):   
Michael C. Winter, Post-Doctoral Fellow; D. Michael Shasby, Professor; Internal Medicine
Project Title:    
The Role of Cadherins in Endothelial Permeability
Year Funded: 
1999
Amount Received: 
$20,000
Publications:
  1. Winter MC, Anant MK, Ries DR, Shasby SS, Chen YT, Shasby DM.  Histamine alters cadherin-mediated sites of endothelial adhesion.  Am J Physiol 1999; 277 (Lung Cell Mol Physiol 21):L988-L995.

 

2000

Investigator(s):   
Iftikar Hussain, Assistant Professor of Clinical Medicine, Internal Medicine; Patrick O’Shaughnessy, Assistant Professor, Preventive Medicine & Environmental Health; Joel Kline, Assistant Professor, Internal Medicine
Project Title:    
Mechanism of Combined Allergen and Nitrogen Dioxide Induced Upper Airway Inflammation
Year Funded: 
2000
Amount Received: 
$20,000
Publications:
  1. Hussain I, Jain V. O’Shaughnessy P, Kline JN. Exposure to Nitrogen Dioxide Induces Tolerance to Airway Hyperresponsiveness in a Murine Model of Asthma. Am J of Resp Critical Care. Submitted 2002.

Investigator(s):   
Michelle Scherer, Assistant Professor, Civil and Environmental Engineering
Project Title:    
Attenuation of Herbicides by Reduced Iron Minerals
Year Funded: 
2000
Amount Received: 
$20,000
Grant Awards:   
  1. CAREER:  National Science Foundation Award 9983719.  M. Scherer, PI. Reactivity of Green Rust Compounds in Natural and Engineered Systems. 6/1/2000 – 5/31/2005.  $312,500.    

Investigator(s):   
Shannon Marquez, Faculty Associate, Occupational and Environmental Health
Project Title:    
Comparative Risk Analysis of Adverse Health Outcomes from Chemical, Biological, and Physical Stressors in Drinking Water
Year Funded: 
2000
Amount Received: 
$20,000

Investigator(s):   
Elaine Smith, Professor, Epidemiology; Leslie Dennis, Assistant Professor, Epidemiology; Laurence Fuortes, Associate Professor, Occupational and Environmental Health; Justine Ritchie, Research Scientist, Biostatistics; Richard Williams, Professor, Urology
Project Title:    
Study of Occupational Exposures and Risk of Prostate Cancer
Year Funded: 
2000
Amount Received: 
$20,000
Publications:
  1. Ritchie JM, Vial SL, Fuortes LJ, Guo H, Reedy VE, Smith EM..  Organochlorines and risk of prostate cancer. J Occup Environ Med. 45(7):692-702, 2003.
Grant Awards:
  1. NIH/NCI: Leslie Dennis, PI, Trace Elements among Iowa Pesticide Applicators, $100,000, from Jul 1, 2003 to Jun 30, 2005.

  Environmental Health Sciences Research Center, The University of Iowa, 100 Oakdale Campus, #178 IREH, Iowa City, IA 52242

Tel: (319) 335-4756 / Fax: (319) 335-4225 / E-mail: nancy-newkirk@uiowa.edu