EHSRC Investigator Detail
| Rama K. Mallampalli, M.D. | |
| Professor of Internal Medicine - Pulmonary |
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| Email: rama-mallampalli@uiowa.edu | |
| Phone: (319) 356-1265 | |
| EHSRC Role(s): | Member, Inflammation and Innate Immunity Research Cluster |
Dr. Mallampalli's research has focused on the regulatory mechanisms for CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme required for the de novo synthesis of phosphatidylcholine. Another area of investigation focuses on the mechanisms by which an important class of inflammatory mediators, the sphingolipids, repress CCT gene transcription. Dr. Mallampalli's group is studying the biochemical pathways by which sphingolipid degradation products are generated in the lung, and their effects on CCT transcriptional activity by molecular analysis of the CCT promoter and by using transgenic approaches.
Recent Publications
- Agassandian M, Miakotina OL, Andrews M, Mathur SN, Mallampalli RK. Pseudomonas aeruginosa and sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARalpha-RXR. Biochem J. 2007 May 1;403(3):409-20.
- Wu Y, Xu Z, Henderson FC, Ryan AJ, Yahr TL, Mallampalli RK. Chronic Pseudomonas aeruginosa infection reduces surfactant levels by inhibiting its biosynthesis. Cell Microbiol. 2007 Apr;9(4):1062-72. Epub 2006 Dec 12.
- Henderson FC, Miakotina OL, Mallampalli RK. Proapoptotic effects of P. aeruginosa involve inhibition of surfactant phosphatidylcholine synthesis. J Lipid Res. 2006 Oct;47(10):2314-24. Epub 2006 Jul 25.
- McCoy DM, Fisher K, Robichaud J, Ryan AJ, Mallampalli RK. Transcriptional regulation of lung cytidylyltransferase in developing transgenic mice. Am J Respir Cell Mol Biol. 2006 Sep;35(3):394-402. Epub 2006 Apr 27.
- Zhou J, Wu Y, Henderson F, McCoy DM, Salome RG, McGowan SE, Mallampalli RK. Adenoviral gene transfer of a mutant surfactant enzyme ameliorates pseudomonas-induced lung injury. Gene Ther. 2006 Jun;13(12):974-85. Epub 2006 Mar 2.
- Ryan AJ, Andrews M, Zhou J, Mallampalli RK. c-Jun N-terminal kinase regulates CTP:phosphocholine cytidylyltransferase. Arch Biochem Biophys. 2006 Mar 1;447(1):23-33. Epub 2006 Jan 24.