ENVIRONMENTAL HEALTH SCIENCES RESEARCH CENTER

A National Institute of Environmental Health Sciences Center of Excellence

 

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Anup Madan, Ph.D.

Assistant Professor of Neurosurgery (Adjunct)

Email: anup-madan@uiowa.edu
Phone: (319) 335-8491
EHSRC Role(s): Associate Member, Inflammation and Innate Immunity Research Cluster

Dr. Madan is currently an independently funded NIH investigator. His group is participating in Mammalian Gene Collection (MGC) initiative to generate full length cDNA resource.

He is also directing an NIH funded microbial genomics program. His group has recently finished genomic sequencing of Mycoplasma gallassepticum, Rickettsia rickettsii, Rickettsia akari and is working on genomes of Mycoplasma capricolum, Rickettsia Canada, Rickettsia bellii, Piscirickettsia salmonis, Orientia tsutsugamushi. The availability of the genomic sequences will be used to design novel tools for epidemiological studies and development of efficient diagnostic systems. Along with Greg Foltz, MD, he is working on the Brain Expression Database to catalogue the diverse repertoire of genes expressed in the human, mouse, rat, drosophila and honey bee brain.

Recent Publications

  1. Philibert RA, Ryu GY, Yoon JG, Sandhu H, Hollenbeck N, Gunter T, Barkhurst A, Adams W, Madan A. Transcriptional profiling of subjects from the Iowa adoption studies. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144(5):683-90.
  2. Philibert RA, Crowe R, Ryu GY, Yoon JG, Secrest D, Sandhu H, Madan A. Transcriptional profiling of lymphoblast lines from subjects with panic disorder. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144(5):674-82.
  3. Vibhakar R, Foltz G, Yoon JG, Field L, Lee H, Ryu GY, Pierson J, Davidson B, Madan A. Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma. Neuro Oncol. 2007 Apr;9(2):135-44. Epub 2007 Feb 28.
  4. Philibert R, Madan A, Andersen A, Cadoret R, Packer H, Sandhu H. Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Am J Med Genet B Neuropsychiatr Genet. 2007 Jan 5;144(1):101-5.
  5. Reeg R, Madan A.  Transposon-mediated sequencing.  Meth Mol Biol 255:197-210, 2004.
  6. Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, and the rest of the MGC Consortium.  The NIH mammalian gene collection of full length cDNAs: Update and the inclusion of additional species.  Genome Res 14(10b):2121-2127, 2004.
  7. Cieslewicz MJ, Chaggin D, Glusman G, Kasper D, Madan A, Rodrigues S, Fahey J, Wessels MR, Robens CE.  Structural and genetic diversity of group B streptococcus capsular polysaccharides.  Infecttion & Immunity 73(5):3096-3103, 2005.
  8. Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C. Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5.
  9. Dokras A, Coffin J, Field L, Frakes A, Lee H, Madan A, Nelson T, Ryu GY, Yoon JG, Madan A.  Epigenetic regulation of maspin expression in the human placenta.  Mol Hum Reprod. 2006 Oct;12(10):611-7.
  10. Foltz G, Ryu GY, Yoon JG, Nelson T, Fahey J, Frakes A, Lee H, Field L, Zander K, Sibenaller Z, Ryken TC, Vibhakar R, Hood L, Madan A. Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma.Cancer Res. 2006 Jul 1;66(13):6665-74.
  11. Wise KS, Foecking MF, Roske K, Lee YJ, Lee YM, Madan A, Calcutt MJ.  Distinctive repertoire of contingency genes conferring mutation- based phase variation and combinatorial expression of surface lipoproteins in Mycoplasma capricolum subsp. capricolum of the Mycoplasma mycoides phylogenetic cluster. J Bacteriol. 2006 Jul;188(13):4926-41. Erratum in: J Bacteriol. 2006 Sep;188(18):6716-7.
  12. Eremeeva ME, Madan A, Shaw CD, Tang K, Dasch GA.  New perspectives on rickettsial evolution from new genome sequences of rickettsia, particularly R. canadensis, and Orientia tsutsugamushi.  Ann N Y Acad Sci. 2005 Dec;1063:47-63.

 

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