EHSRC Investigator Detail
| Gabriele Ludewig, Ph.D. | |
| Associate Professor of Occupational & Environmental Health |
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| Email: gabriele-ludewig@uiowa.edu | |
| Phone: (319) 335-4650 | |
| Iowa Superfund Basic Research Program | |
| University of Iowa Department of Occupational & Environmental Health | |
| The University of Iowa Interdisciplinary Graduate Program in Human Toxicology | |
| EHSRC Role(s): | Member, Oxidative Stress and Metabolism Research Cluster |
Dr. Ludewig is conducting research in the mechanisms of toxicity, genotoxicity and carcinogenicity of compounds found as contaminants in food and the environment. She devotes special emphasis to the study of halogenated compounds, such as polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs).
Recent Publications
- Lehmann L, L Esch H, A Kirby P, W Robertson L, Ludewig G. 4-monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats. Carcinogenesis. 2007 Feb;28(2):471-8. Epub 2006 Aug 31.
- Ptak A, Ludewig G, Kapiszewska M, Magnowska Z, Lehmler HJ, Robertson LW, Gregoraszczuk EL. Induction of cytochromes P450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary. Toxicol Lett. 2006 Oct 25;166(3):200-11. Epub 2006 Jul 14.
- Bender RP, Lehmler HJ, Robertson LW, Ludewig G, Osheroff N. Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. Biochemistry. 2006 Aug 22;45(33):10140-52.
- Ptak A, Ludewig G, Robertson L, Lehmler HJ, Gregoraszczuk EL. In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity. Toxicol Lett. 2006 Jul 1;164(2):113-22. Epub 2006 Jan 18.
- Kodavanti PR, Ward TR, Ludewig G, Robertson LW, Birnbaum LS. Polybrominated diphenyl ether (PBDE) effects in rat neuronal cultures: 14C-PBDE accumulation, biological effects, and structure-activity relationships. Toxicol Sci. 2005 Nov;88(1):181-92. Epub 2005 Aug 17.
- Kania-Korwel I, Hornbuckle KC, Peck A, Ludewig G, Robertson LW, Sulkowski WW, Espandiari P, Gairola CG, Lehmler HJ. Congener-specific tissue distribution of aroclor 1254 and a highly chlorinated environmental PCB mixture in rats. Environ Sci Technol. 2005 May 15;39(10):3513-20.
- Ptak A, Ludewig G, Lehmler HJ, Wojtowicz AK, Robertson LW, Gregoraszczuk EL. Comparison of the actions of 4-chlorobiphenyl and its hydroxylated metabolites on estradiol secretion by ovarian follicles in primary cells in culture. Reprod Toxicol. 2005 May-Jun;20(1):57-64.