Environmental Health Sciences Research Center

EHSRC Investigator Detail

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Joel N. Kline, M.D.
Professor of Medicine and Occupational & Environmental Health
Email: joel-kline@uiowa.edu
Phone: (319) 353-8551
EHSRC Role(s):	Center Deputy Director
	Director, Inflammation and Innate Immunity Research Cluster
	Director, Integrative Health Sciences Facility
	Member, Genomics Initiative

Dr. Kline leads successful clinical/translational as well as basic research programs in asthma and airway inflammation. He was the first to report the effects of CpG DNA (bacterial-like sequences) on modulating topic airway inflammation, and subsequently he has continued to explore the properties of microbial/commensal organisms and their products on regulating innate immune responses. Dr. Kline’s research studies have resulted in a number of honors and awards. He is frequently invited to present his studies at national and international conferences, and he serves as a regular member of the Lung Cell and Molecular Immunology Study Section, in addition to ad hoc reviews for other study sections and granting agencies.

Within the Department of Medicine, Dr. Kline directed the Occupational Medicine Section from 2001-2005. This position required leadership of clinical, educational, and research efforts. In 2004, he was asked to develop and lead the University of Iowa Asthma Center, which he continues to this time. The Asthma Center promotes excellence in the treatment and study of asthma, with strong basic, translational, and clinical asthma research programs. The goals of the Asthma Center are strongly aligned with those of the EHSRC.

Recent Publications

Kline JN. Eat dirt: CpG DNA and immunomodulation of asthma. Proc Am Thorac Soc. 2007 Sep;4(3):283-8.
Kemeny ME, Rosenwasser LJ, Panettieri RA, Rose RM, Berg-Smith SM, Kline JN. Placebo response in asthma: a robust and objective phenomenon. J Allergy Clin Immunol. 2007 Jun;119(6):1375-81. Epub 2007 Apr 23.
Heederik D, Sigsgaard T, Thorne PS, Kline JN, Avery R, Bonlokke JH, Chrischilles EA, Dosman JA, Duchaine C, Kirkhorn SR, Kulhankova K, Merchant JA. Health effects of airborne exposures from concentrated animal feeding operations. Environ Health Perspect. 2007 Feb;115(2):298-302. Epub 2006 Nov 14.
Kitagaki K, Businga TR, Racila D, Elliott DE, Weinstock JV, Kline JN. Intestinal helminths protect in a murine model of asthma. J Immunol. 2006 Aug 1;177(3):1628-35.
Sigurdarson ST, Kline JN. School proximity to concentrated animal feeding operations and prevalence of asthma in students. Chest. 2006 Jun;129(6):1486-91.
Chao SS, Graham SM, Brown CL, Kline JN, Hussain I. Cysteinyl leukotriene 1 receptor expression in nasal polyps. Ann Otol Rhinol Laryngol. 2006 May;115(5):394-7.
Sundy JS, Wood WA, Watt JL, Kline JN, Schwartz DA. Safety of incremental inhaled lipopolysaccharide challenge in humans. J Endotoxin Res. 2006;12(2):113-9.
George CL, White ML, Kulhankova K, Mahajan A, Thorne PS, Snyder JM, Kline JN. Early exposure to a nonhygienic environment alters pulmonary immunity and allergic responses. Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L512-22. Epub 2006 Mar 23.
Kitagaki K, Businga TR, Kline JN. Oral administration of CpG-ODNs suppresses antigen-induced asthma in mice. Clin Exp Immunol. 2006 Feb;143(2):249-59.
Casale TB, Busse WW, Kline JN, Ballas ZK, Moss MH, Townley RG, Mokhtarani M, Seyfert-Margolis V, Asare A, Bateman K, Deniz Y; Immune Tolerance Network Group. Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis. J Allergy Clin Immunol. 2006 Jan;117(1):134-40. Epub 2005 Dec 2.