Environmental Health Sciences Research Center

EHSRC Investigator Detail

COEC

Gary W. Hunninghake, M.D.
Sterba Professor of Medicine and Division Director
Email: gary-hunninghake@uiowa.edu
Phone: (319) 335-4187
EHSRC Role(s):	Co-Director, Inflammation and Innate Immunity Research Cluster

Dr. Hunninghake's clinical and research interests include the areas of sarcoidosis, asthma, occupational lung disease, and interstitial lung disease. His studies emphasize molecular and cellular biology, virology and second messenger studies.

Dr. Hunninghake is also the Director of the Graduate Program in Translational Biomedical Research and the Director of the Training Program in Molecular and Cellular Biology of the Lung.

Recent Publications

Ashare A, Monick MM, Nymon AB, Morrison JM, Noble M, Powers LS, Yarovinsky TO, Yahr TL, Hunninghake GW. Pseudomonas aeruginosa Delays Kupffer Cell Death via Stabilization of the X-Chromosome-Linked Inhibitor of Apoptosis Protein. J Immunol. 2007 Jul 1;179(1):505-13.
2: Baran CP, Opalek JM, McMaken S, Newland CA, O'brien JM Jr, Hunter MG, Bringardner BD, Monick MM, Brigstock DR, Stromberg PC, Hunninghake GW, Marsh CB. Important Roles for Macrophage Colony-stimulating Factor, CC Chemokine Ligand 2, and Mononuclear Phagocytes in the Pathogenesis of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2007 Jul 1;176(1):78-89. Epub 2007 Apr 12.
3: Yarovinsky TO, Butler NS, Monick MM, Hunninghake GW. Early exposure to IL-4 stabilizes IL-4 mRNA in CD4+ T cells via RNA-binding protein HuR. J Immunol. 2006 Oct 1;177(7):4426-35.
4: Dajani R, Sanlioglu S, Zhang Y, Li Q, Monick MM, Lazartigues E, Eggleston T, Davisson RL, Hunninghake GW, Engelhardt JF. Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS. Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G242-52. Epub 2006 Aug 24.
5: Monick MM, Powers LS, Gross TJ, Flaherty DM, Barrett CW, Hunninghake GW. Active ERK contributes to protein translation by preventing JNK-dependent inhibition of protein phosphatase 1. J Immunol. 2006 Aug 1;177(3):1636-45.
6: Nyunoya T, Monick MM, Klingelhutz A, Yarovinsky TO, Cagley JR, Hunninghake GW. Cigarette smoke induces cellular senescence. Am J Respir Cell Mol Biol. 2006 Dec;35(6):681-8. Epub 2006 Jul 13.
7: Dasgupta N, Ashare A, Hunninghake GW, Yahr TL. Transcriptional induction of the Pseudomonas aeruginosa type III secretion system by low Ca2+ and host cell contact proceeds through two distinct signaling pathways. Infect Immun. 2006 Jun;74(6):3334-41.
8: Groskreutz DJ, Monick MM, Powers LS, Yarovinsky TO, Look DC, Hunninghake GW. Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells. J Immunol. 2006 Feb 1;176(3):1733-40.
9: Ashare A, Monick MM, Powers LS, Yarovinsky T, Hunninghake GW. Severe bacteremia results in a loss of hepatic bacterial clearance. Am J Respir Crit Care Med. 2006 Mar 15;173(6):644-52. Epub 2006 Jan 6.