ENVIRONMENTAL HEALTH SCIENCES RESEARCH CENTER
A National Institute of Environmental Health Sciences Center of Excellence

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EHSRC Investigator Detail

Dr. Goswami's laboratory is pursuing mechanistic understanding of the role intracellular redox-state plays in regulating the mammalian cell cycle, and the establishment of a link between ROS-signaling and other aspects of intracellular signaling networks.

Research efforts are concentrated in identifying the molecular mechanisms involved in the regulation of the redox-sensitive G1-checkpoint following mitogenic stimuli and in asynchronously growing exponential cells. The possible role of ROS and thiol-redox reactions in regulating expression and activities of cyclins, CDKs, CKIs, CDC25, Rb, thioredoxin, and glutaredoxin are of immediate interest.

Research efforts are also ongoing identifying the cellular effects of environmental pollutants, polychlorinated biphenyls. The possible role of oxidative stress in PCB-induced DNA damage, perturbation in cellular proliferation, and cell death is currently being investigated.

Additional research interest includes investigating the possible role of intracellular redox environment in radiosensitivity, radiation-induced cell cycle checkpoint pathways, and post-transcriptional gene regulation.

The knowledge gained from these research projects may provide novel insights into the regulation of the mammalian cell cycle both in physiological as well as pathological states. This knowledge may allow us to devise better treatment protocols based on redox control of the cell cycle.

Recent Publications

1. Menon SG, Sarsour EH, Kalen AL, Venkataraman S, Oberley LW, and Goswami PC. Superoxide signaling mediates N-acetyl-L-cysteine induced G1 arrest: Regulatory role of manganese superoxide dismuatase and cyclin D1.  Cancer Research, 2007, 67:6392-6399.

2. Menon SG, and Goswami PC. A redox cycle within the cell cycle: Ring in the old with the new. Oncogene 2007, 26:1101-1109.

3. Bock JM, Menon SG, Sinclair LL, Bedford NS, Goswami PC, Domann RE, and Trask DK.  Celecoxib toxicity is cell cycle phase specific.  Cancer Research, 2007, 67:3801-3808.

4. Slane BG, Akyin-Burns N, Smith BJ, Kalen AL, Goswami PC, Domann FE, and Spitz DR. Mutation of succinate dehydrogenase subunit C (SDHC) results in increased O2·-, oxidative stress and genomic instability. Cancer Research, 66(15) 7615-7620, 2006.

5. Li Hualei, Goswami PC, and Domann FE. AP2-g induces p21 expression, arrest cell cycle, and inhibits tumor growth of human cancer cells.  Neoplasia, 8(7) 568-577, 2006.

6. Kalen AL, Sarsour EH, Venkataraman S, and Goswami PC. Mn-superoxide dismutase over expression enhances G2-accumulation and radioresistance in human oral squamous carcinoma cells. Antioxidants & Redox Signaling, 8:1273-1281, 2006.

7. Sarsour EH, Agarwal M, Pandita TK, Oberley LW, and Goswami PC. Manganese superoxide dismutase protects the proliferative capacity of confluent normal human fibroblasts. J. Biol. Chem. 280:18033-18041, 2005.

8. Menon SG, Sarsour EH, Spitz DR, Higashikubo R, Sturm M, Zhang H and Goswami PC. Redox regulation of the G1 to S transition in the mouse embryo fibroblast cell cycle. Cancer Research 63, 2109-2117, 2003.

  Environmental Health Sciences Research Center, The University of Iowa, 100 Oakdale Campus, #178 IREH, Iowa City, IA 52242

Tel: (319) 335-4756 / Fax: (319) 335-4225 / E-mail: nancy-newkirk@uiowa.edu