EHSRC Investigator Detail
| A. Brent Carter, MD | |
| Assistant Professor in Internal Medicine |
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| Email: brent-carter@uiowa.edu | |
| Phone: (319) 353-7852 | |
| EHSRC Role(s): | Member, Inflammation and Innate Immunity Research Cluster |
Dr. Carter's clinical interests include asthma, interstitial lung disease, and acute lung injury. His research interests include studies related to the regulation of inflammatory responses that occur in the lung in models of acute lung injury and asbestos-induced lung disease. These studies include investigations dealing with the role of reactive oxygen species in the development of inflammatory response and the regulation of the signal transduction pathways that lead to cytokine gene expression in monocytes and macrophages exposed to asbestos. This work is supported by a Merit Grant from the Department of Veteran’s Affairs and a Career Investigator Award from the American Lung Association.
Recent Publications
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Tephly LA, Carter AB. Differential Expression and Oxidation of MKP-1 Modulates TNF-{alpha} Gene Expression. Am J Respir Cell Mol Biol 37:366-374, 2007.
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Agassandian M., Zhou J., Tephly, L.A., Ryan, A.J., Carter A. B., and Mallampalli, R.K. Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation CTP:Phosphocholine Cytidylyltranferase. J. Biol. Chem. 280:21577-21587, 2005
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Tephly, L.A. and Carter, A.B. Constitutive NADPH Oxidase and Increased Mitochondrial Respiratory Chain Activity Regulate Chemokine Gene Expression. Am J Physiol: Lung Cell Mol Physiol (In Press).
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Carter, A.B., Tephly, L.A., Venkataraman, S., Oberley, L.W., Zhang, Y., Buettner, G. R., Spitz, D.R. and Hunninghake, G.W. High levels of catalase and glutathione peroxidase activity dampens hydrogen peroxide signaling in human alveolar macrophages. Am. J. Resp. Cell Mo. Biol. 31:43-53, 2004.