Environmental Health Perspectives 115(2):296-320, 2007

Entire Publication Series

Environmental Health Impacts of Concentrated Animal Feeding Operations (CAFOs)

Individual Publications

Environmental Health Impacts of CAFOs (Introduction to the series)

Health Effects of Airborne Exposures from CAFOs

Monitoring and Modeling of Emissions from CAFOs

Impacts of Waste from CAFOs on Water Quality

The Potential Role of CAFOs in Infectious Disease Epidemics and Antibiotic Resistance

Community Health and Socioeconomic Issues Surrounding CAFOs

• Aarestrup FM, Seyfarth AM, Emborg H-D, Pedersen K, Hendriksen RS, Bager F.  2001. Effect of abolishment of the use of antimicrobial agents for growth promotion on occurrence of antimicrobial resistance in fecal enterococci from food animals in Denmark.  Antimicrob Agents Chemother 45:2054-2059.
• Abeles-Allison M, Conner L. 1990.  An analysis of local benefits and costs of Michigan hog operation experiencing environmental conflicts.  Department of Agricultural Economics, Michigan State University, East Lansing.
• Aneja VP, Nelson DR, Roelle PA, Walker JT.  2003. Agricultural ammonia emissions and ammonium concentrations associated with aerosols and precipitation in the southeast United States.  J Geophys Res 108(D4):ACH12-1 – 12-11.
• Arbuckle TE, Sherman GJ, Corey PN, Walters D, Lo B.  1988. Water nitrates and CNS birth defects: a population-based case-control study.  Arch Environ Health 43:162-167.
  ASTM (American Standards of Testing and Measurement).  E1432-91: Standard practice for defining and calculating individual and group sensory thresholds from forced-choice data sets of intermediate size.  ASTM International.  1997a. West Conshohocken, PA.
• ASTM (American Standards of Testing and Measurement).  E679-91: Standard practice for determination of odor and taste thresholds by a forced-choice ascending concentration series method of limits.  ASTM International.  1997b. West Conshohocken, PA.
• Attwood P, Brouwer R, Ruigewaard P, Versloot P, de Wit R, Heederik D, Boleij JS. 1987. A study of the relationship between airborne contaminants and environmental factors in Dutch swine confinement buildings. Am Ind Hyg Assoc J 48(8):745-751.
• Avery R, Wing S, Marshall S, Schiffman S. 2004. Odor from industrial hog farming operations and mucosal immune function in neighbors. Arch Environ Health 59(2):101-108.
• Barker JC, Zublena JP.  1995. Livestock Manure Nutrient Assessment in North Carolina.  Final Report.  Raleigh, NC: North Carolina Agricultural Extension Service, North Carolina State University.
• Barnes KK, Christenson SC, Kolpin DW, Focazio MJ, Furlong ET, Zaugg SD, Meyer MT. 2004.  Pharmaceuticals and other organic wastewater contaminants within a leachate plume downgradient of a municipal landfill.Ground Water Monitoring and Remediation 24(2):119-126.
• Barrett JH, Parslow RC, McKinney PA, Law GR, Forman D.  1998. Nitrate in drinking water and the incidence of gastric, esophageal, and brain cancer in Yorkshire, England.  Cancer Causes Control 9:153-159.
• Bottcher RW. 2001. An environmental nuisance: Odor concentrated and transported by dust.  Chem Senses 26: 327-331.
• Boxall AB, Fogg LA, Blackwell PA, Kay P, Pemberton EJ, Croxford A. 2004. Veterinary medicines in the environment.  Rev Environ Contam Toxicol 180:1-91.
• Braun-Fahrländer C, Gassner M, Grize L, Neu U, Sennhauser FH, Varonier HS, Vuille JC, Wüthrich B.  1999. Prevalence of hay fever and allergic sensitization in farmer’s children and their peers living in the same rural community. Clin Exp Allergy 29:28-34.
• Braun-Fahrländer CH, Riedler J, Herz U, Eder W, Waser M, Grize L, et al. 2002. Environmental exposure to endotoxin and its relation to asthma in school-age children. NEJM 347(12):869-877.
• Bullers, S. 2005.   Environmental Stressors, Perceived Control, and Health: The Case of Residents Near Large-Scale Hog Farms in Eastern North Carolina .  Human Ecology, 33:1-16.
• Bunton B, O'Shaughnessy P, Fitzsimmons S, Gering J, Hoff S, Lyngbye M, Thorne PS, Wasson J, Werner M. Modeling and monitoring of emissions from CAFOs, Environ Health Perspect, this issue, 2005.
• Burkholder J, Libra RD, Weyer P, Heathcote S, Kolpin D, Wichman M.  Impacts of CAFOs on water quality.  Workgroup report, “Environmental health impacts of CAFOs: anticipating hazards – searching for solutions.”  Iowa City, Iowa, March 29-31, 2004.
• Burkholder JM, Mallin MA, Glasgow HB, Larsen LM, McIver MR, Shank GC, Deamer-Melia N, Briley DS, Springer J, Touchette BW, and Hannon EK. 1997. Impacts to a coastal river and estuary from rupture of a large swine waste holding lagoon.  J Environ Qual 26:1451-1466.
• Burkholder JM, Mason KM, Glasgow HB.  1992. Water-column nitrate enrichment promotes decline of eelgrass (Zostera marina L.): Evidence from seasonal mesocosm experiments.  Mar Ecol Prog Ser 81:163-178.
• Burkholder JM. 2002. Cyanobacteria, pp. 952-982. In: Encyclopedia of Environmental Microbiology (Bitton G, ed.). Wiley Publishers, New York, 952-982.
• Burnison BK, Hartmann A, Lister A, Servos MR, Ternes T, Van der Kraak G.  2003. A toxicity identification evaluation approach to studying estrogenic substances in hog manure and agricultural runoff.  Env Toxicol Chem 22:2243-2250.
• Campagna D, Kathman S, Inserra SG, Phifer BL, Middleton DC, White MC.  2001. Impact of ambient hydrogen sulfide and total reduced sulfur levels on hospital visits for respiratory diseases among children and adults in Dakota City and South Sioux City, Nebraska.  Am J Respir Crit Care Med 163(5):A562.
• Campagna D, Kathman SJ, Pierson R, Inserra SG, Phifer BL, Middleton DC, Zarus GM, White MC. 2004. Ambient hydrogen sulfide, total reduced sulfur, and hospital visits for respiratory diseases in northeast Nebraska, 1998-2000. J Expo Anal Environ Epidemiol 14(2):180-187.
• Campagnolo ER, Johnson KR, Karpati A, Rubin CS, Kolpin DW, Meyer MT, Esteban JE, Currier RW, Smith K, Thu KM, McGeehin M.  2002. Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations.  The Science of the Total Environment 299:89-95.
• Cantor KP.  1997. Drinking water and cancer.  Cancer Causes Control 8:292-308.
• Cantrell P, Perry R, Sturtz P.  1996. Hog Wars: The Corporate Grab for Control of the Hog Industry and How Citizens are Fighting Back. Culture and Agriculture 18(2):86-91. Available: http://www.anthrosource.net/doi/pdf/10.1525/cag.1996.18.2.86 [accessed 26 September 2005].
• Carmichael WW, Azevedo SM, An JS, Molica RJ, Jochimsen EM, Lau S, Rinehart KL, Shaw GR, Eaglesham GK. 2001. Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins.  Environ Health Perspect 109:663-668.
• Carney PG, Dodd VA. 1989. A comparison between predicted and measured values for the dispersion of malodours from slurry.  J Agric Engng Res 44(1):67-76.
• Casewell M, Friis, C Marco E, McMullin P, Phillips I.  2003. The European ban on growth-promoting antibiotics and emerging consequences for human and animal health.  J  Antimicrobi Chemother 52:159-161.
• CDC (Centers for Disease Control). Avian influenza infection in humans.  2005. Available: http://www.cdc.gov/flu/avian/gen-info/avian-flu-humans.htm  [accessed 26 September 2005].
• Center for Rural Affairs. 2000. Testimony before the United State Senate Judiciary Committee Field Hearing ensuring Competitive and Open Markets in Agriculture: Are Meatpackers Abusing Market Power? Sioux Falls South Dakota, August, 2002.  Available at: http://www.cfra.org/resources/Testimony/open_market_testimony.htm  [accessed 26 September 2005].
• Chapin A, Boulind C, Moore A.  Controlling Odor and Gaseous Emission Problems from Industrial Swine Facilities: A Handbook for All Interested Parties.  Yale Environmental Protection Clinic. 1998.
• Chee-Sanford JC, Aminov RI, Krapac IJ, Garrigues-Jeanjean N, Mackie RI.  2001. Occurrence and diversity of Tetracycline resistance genes in lagoons and groundwater underlying two swine production facilities.  Appl Environ Microbiol 67(4):1494-1502.
• Childers JW, Thompson EL, Harris D, Kirchgessner M, Clayton D, Natschke, Phillips W. 2001. Multi-pollutant concentration measurements around a concentrated swine production facility using open-path FTIR spectrometry.  Atmospheric Environment 35:1923-1936.
• Chism JW, Levins RA.  1994. Farm spending and local selling: How do they match up? Minnesota Agricultural Economist 676:1-4.
• Chua KB, Goh KJ, Wong KT, Kamarulzaman A, Tan PS, Ksiazek TG, Zaki SR, Paul G, Lam SK, Tan CT. 1999. Fatal encephalitis due to Nipah virus among pig-farmers in Malaysia.  Lancet 354(9186):1257-1259.
• Cordy G, Duran N, Bower H, Rice R, Kolpin DW, Furlong ET, et al. 2004. Do pharmaceuticals, pathogens, and other organic wastewater compounds persist when wastewater is used for recharge? Ground Water Monitoring and Remediation 24(2):58-69.
• Cormier Y, Duchaine C, Israël-Assayag E, Bédard G, Laviolette M, Dosman J. 1997. Effects of repeated swine building exposures on normal naïve subjects.  Eur Respir J 10:1516-1522.
• Croen LA, Todoroff K, Shaw GM. 2001. Maternal exposure to nitrate from drinking water and diet and risk for neural tube defects.  Am J Epidemiol153:325-331.
• Cuello C, Correa P, Haenszel W, Gordillo G, Brown C, Archer M, Tannenbaum S. 1976. Gastric cancer in Columbia.  1.  Cancer risk and suspect environmental agents.  J Natl Cancer Inst 57:1015-1020.
• DANMAP. 2004. Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, foods and humans in Denmark.  H-D Emborg, OE Heuer and PB Larsen, Eds.  Søborg, Denmark: Danish Integrated Antimicrobial Resistance Monitoring and Research Programme.  Available: www.vetinst.dk.  [accessed 26 September 2005].
• Daughton CG, Ternes TA. 1999. Pharmaceuticals and personal care products in the environment: Agents of subtle change? Environ Health Perspec 107:907-938.
• De Roos AJ, Ward MH, Lynch CF, Cantor KP.  2003. Nitrate in public water supplies and the risk of colon and rectum cancers.  Epidemiology 14:640-649.
• Delepee R, Pouliquen H, Le Bris H. 2004. The bryophyte Fontinalis antipyretica Hedw. bioaccumulates oxytetracycline, flumequine and oxolinic acid in the freshwater environment. The Science of the Total Environment 322:243-253.
• DeLind LB. 1998. Parma, a story of hog hotels and local resistance.  In Pigs, profits, and rural communities. Thu K, Durrenberger EP, Eds.  State University of New York Press 23-38.
• Donham K, Haglind P, Peterson Y, Rylander R. 1986.  Environmental and health studies in swine confinement buildings.  Am J Ind Med 10:289-293.
• Donham KJ, Cumro D, Reynolds S.  2002. Synergistic effects of dust and ammonia on the occupational health effects of poultry workers.  J Agromed 8(2):57-76.
• Donham KJ, Cumro D, Reynolds SJ, Merchant JA. 2000. Dose-response relationships between occupational aerosol exposures and cross-shift declines of lung function in poultry workers: recommendations for exposure limits. J Occup Environ Med 42(3):260-269.
• Donham KJ, Knapp L, Monson R, Gustafson K. 1982. Acute toxic exposure to gases from liquid manure.  J Occup Med 24:142-145.
• Donham KJ, Merchant J, Lassise D, Popendorf W, Burmeister L. 1990.  Preventing respiratory disease in swine confinement workers: Intervention through applied epidemiology, education and consultation.  Am J Ind Med 18:241-261.
• Donham KJ, Rubino M, Thedell TD, Kammermeyer J.  1977. Potential health hazards to agricultural workers in swine confinement buildings.  J Occup Med 19(6):383-387. 
• Donham KJ, Zavala DC, Merchant JA. 1984. Respiratory symptoms and lung function among workers in swine confinement buildings: a cross-sectional epidemiological study. Arch Environ Health 39(2):96-101.
• Douwes J, Doekes G, Heinrich J, Koch A, Bischof W, Brunekreef B. 1998. Endotoxin and ß(1®3)-glucan in house dust and the relation with home charac­te­ristics: A pilot study in 25 German houses. Indoor Air 8:255-263.
• Douwes J, Heederik D. 1997. Epidemiologic investigations of endo­toxins. Int J Occ Env Health 3 (suppl 1):S26-31.
• Douwes J, Pearce N, Heederik D. 2002. Does environmental endotoxin exposure prevent asthma? Thorax 57(1):86-90.
• Douwes J, Zuidhof A, Doekes G, van der Zee SC, Wouters I, Boezen MH, Brunekreef B.  2000. ß(1®3)-glucan and endotoxin in house dust and peak flow variability in children. Am J Resp Crit Care Med 162:1348-1354.
• Durrenberger P, Thu KM. 1996. The Expansion of Large Scale Hog Farming in Iowa: The Applicability of Goldschmidt’s Findings Fifty Years Later.” Human Organization 55(4):409-415.
• Earth Tech.  Final technical work paper for air quality and odor impacts. 2001.  Prepared for the Generic Environmental Impact Statement on Animal Agriculture. Saint Paul, MN: Environmental Quality Board.  Available: http://www.eqb.state.mn.us/geis/TWP_AirQuality.pdf  [accessed 26 September 2005].
• Eder W, Klimecki W, Yu L, von Mutius E, Riedler J, Braun-Fahrländer C, Nowak D, Martinez FD; ALEX Study Team. 2004. Toll-like receptor 2 as a major gene for asthma in children of European farmers. J Allergy Clin Immunol 113(3):482-488.
• Eduard W, Douwes J, Omenaas E, Heederik D. 2004. Do farming exposures cause or prevent asthma? Results from a study of adult Norwegian farmers. Thorax59(5):381-386.
• Eicholzer M, Gutzwiller F. 1990. Dietary nitrates, nitrites and N-nitroso compounds and cancer risk: a review of the epidemiologic evidence.  Nutr Rev 56:95-105.
• EPAV. Environment Protection Authority, Government of Victoria, Melbourne, Australia. 2000. Ausplume Gaussian Plume Dispersion Model, Technical User Manual.
• Erisman JW, Otjes R, Hensen A, Jongejan P, van den Bulk P, Khlystov A, Möls H,  Slanina S. 2001.  Instrument development and application in studies and monitoring of ambient ammonia.  Atmospheric Environment 35:1913-1922.
• Ernst P, Cormier Y. 2000. Relative scarcity of asthma and atopy among rural adolescents raised on a farm. Am J Respir Crit Care 161(5):1563-1566.
• Evans, RO, Westerman PW, Overcash MR. 1984. Subsurface drainage water quality from land application of swine lagoon effluent.  Trans Amer Soc Agric Eng 27:473-480.
• Extension Toxicology Network.  Exotoxnet – A Pesticide Information Project of the Cooperative Extension Offices of Cornell University, Michigan State University, Oregon State University, and the University of California at Davis.  USDA, Extension Service, and the National Agricultural Pesticide Impact Assessment Program.  2003. Available:  http://ace.orst.edu/info/extoxnet/  [accessed 26 September 2005].
• Fernandez C, Alonso C, Babin MM, Pro J, Carbonell G, Tarazona JV. 2004. Ecotoxicological assessment of doxycycline in aged pig manure using multispecies soil systems. The Science of the Total Environment 323:63-69.
• Fishwick D, Pearce N, D’Souza W, Town I, Armstrong R, Kogevinas M, Crane J. 1997. Occupational asthma in New Zealanders: a population based study. Occup Environ Med 54:301-306.
• Foltz JD, Jackson-Smith D, Chen L.  Do Purchasing Patterns Differ Between Large and Small Dairy Farms?  Econometric Evidence from Three Wisconsin Communities.  Agricultural and Resource Economics Review.  Spring, 2002.
• Fritz BK, Shaw BW, Parnell CV Jr.  2002. Dispersion modeling of particulate from low-level point sources.  ASAE Paper No. 024019, St. Joseph, MI: American Society of Agricultural Engineers.
• Gassman PW, Bouzaher A. 1995. Livestock pollution: lessons from the European Union.  In: Animal waste and the land-water interface (Steele, K, ed.). Boca Raton, FL: Lewis Publishers, 215-222.
• Gassman PW. 1992. Simulation of odor transport: A review.  ASAE Paper No. 92-4517, St. Joseph, MI: American Society of Agricultural Engineers.
• Gereda JE, Leung DYM, Liu AH. 2000a. Levels of environmental endotoxin and prevalence of atopic disease [Letter]. JAMA 284:1652-1653.
• Gereda JE, Leung DYM, Thatayatikom A, Price MR, Klinnert MD, Liu AH. 2000b. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 355:1680-1683.
• Gilchrist M, Greko C, Thorne PS, Wallinga D, Riley D, Beran G. The potential role of CAFOs in infectious disease epidemics and antibiotic resistance, Environ Health Perspect, this issue, 2005.
• Gioannini TL, Teghanemt A, Zarember KA, Weiss JP. 2003. Regulation of interactions of endotoxin with host cells. J Endotoxin Res 9(6):401-408.
• Glibert PM, Seitzinger S, Heil CA, Burkholder JM, Parrow MW, Codispoti LA, Kelly V. 2005. Eutrophication – new perspectives on its role in the global proliferation of harmful algal blooms. Oceanography 18:198-209.
• Goldschmidt W.  1978. Agribusiness and the rural community.  In: As You Sow: Three Studies in the Social Consequence of Agribusiness.  Montclair, NJ: Allenheld, Osmun, and Co. [First published as Small Business and the Community: A study in Central Valley of California on effects of scale of farm operations. Report of the Special Committee to Study Problems of American Small Business, United States Senate, December 23, 1946, U.S. Government Printing Office, Washington, D.C., 1946.]
• Gomez MI, Zhang L. 2000. Impacts of concentration in hog production on economic growth in rural Illinois: An economic analysis.  American Agricultural Association Annual Meeting, Tampa FL.  Available: http://www.factoryfarm.org/docs/Gomez.pdf [accessed 26 September 2005].
• Greer FR, Shannon, M, the Committee on Nutrition and the Committee on Environmental Health. 2005. Infant Methemoglobinemia: The Role of Dietary Nitrate in Food and Water. Pediatrics 116(3): 784-786; doi:10.1542/peds.2005-1497.
• Guo H, Jacobson LD, Schmidt D, Nicolai RE. 2001. Simulation of odor dispersions as impacted by weather conditions.  Proceedings of the 6th International Livestock Environment Symposium, 21-23 May, 2001, Louisville, KY.
• Halling-Sorensen B, Sengelov G, Ingerslev F, Jensen LB. 2003. Reduced antimicrobial potencies of oxytetracycline, tylosin, sulfadiazine, streptomycin, ciprofloxacin, and olaquindox due to environmental processes. Archives of Environmental Contamination and Toxicology 44:7-16.
• Hamed M, Johnson TG, Miller KK. 1999. The Impacts of Animal Feeding Operations on Rural Land Values. Columbia, Missouri: University of Missouri-Columbia, Community Policy Analysis Center, May 1999. Available: http://www.cpac.missouri.edu/library/reports/landvalue-saline/landvalues.pdf [accessed 26 September 2005].
• Hamilton ND.  1998. Right-to-farm laws reconsidered: Ten reasons why legislative efforts to resolve agricultural nuisances may be ineffective.  Drake Journal of Agricultural Law 3(1):104.
• Hamscher B, Pawelzick HT, Sczesny S, Nau H, Hartung J. 2003. Antibiotics in dust originating from a pig-fattening farm: A new source of health hazard for farmers? Environmental Health Perspectives 111(13):1590-1594.
• Harris D, Thompson B, Vogel C, Hashmonay R, Natschke D, Wagoner K, et al. 2001.  Innovative approach for measuring ammonia and methane fluxes from a hog farm using open-path Fourier transform infrared spectroscopy, Proceedings of the 94th Annual Conference of the Air and Waste Management Association, VIP-102-CD, Air and Waste Management Association, Pittsburg, PA.
• Hashmonay RM, Yost M, Mamane Y, Benayahu Y. 1999b. Emission rate apportionment from fugitive sources using open-path FTIR and mathematical inversion. Atmospheric Environment 33:735-743.
• Hashmonay RM, Yost M, Wu C. 1999a. Computed tomography of air pollutants using radial scanning path-integrated optical remote sensing. Atmospheric Environment 33:267-274.
• Heber AJ. Setbacks for sufficient swine odor dispersion and dilution.  Presented at: Livestock and Environment Symposium, 10-11 December, 1997, Columbus, Nebraska: University of Nebraska Cooperative Extension Service.
• Herriges JA, Secchi S, Babcock BA. 2003. Living with hogs in Iowa: the impact of livestock facilities on rural residential property values.  Working Paper 03-WP 342.  Center for Agricultural and Rural Development, Iowa State University.  August 2003.   Available: http://www.card.iastate.edu/publications/DBS/PDFFiles/03wp342.pdf  [accessed 26 September 2005].
• Hirsch R, Ternes T, Haberer K, Kratz KL. 1999. Occurrence of antibiotics in the aquatic environment.  Science of the Total Environment 225:109-118.
• Hitzfield BC, Hoger SJ, Dietrich DR. 2000.  Cyanobacterial toxins: Removal during drinking water treatment, and human risk assessment.  Environ Health Perspec 108:113-122.
• Hodne CJ.  Posttraumatic Stress Disorder: Causes, symptoms, and prevention.  ICASH Annual Meeting, West Des Moines, Iowa, November 8-9, 2001.
• Huddleston JH. 1996.  How soil properties affect groundwater vulnerability to pesticides contamination.  Oregon State Extension Service.  Available: http://wwwagcomm.ads.orst.edu/AgComWebFile/EdMat/EM8559.pdf  [accessed 26 September 2005].
• IDSA (Infectious Diseases Society of America).  2005. Bad Bugs, No Drugs Executive Summary: Antibiotic-Resistant Bacterial Pathogens: Why We Are Concerned.  Available: http://www.idsociety.org/  [accessed 26 September 2005].
• IOM (Institute of Medicine). 1998. Antimicrobial Resistance:  Issues and Options.  Forum on emerging infections (Harrison PF and Lederberg J, eds). Division of Health Sciences Policy, Institute of Medicine.  Washington DC:  National Academy Press.
• Iowa State University and the University of Iowa Study Group. 2002. Iowa concentrated animal feeding operations air quality study, University of Iowa, pp. 1-221. Available: http://www.ehsrc.org [accessed 10 October 2005].
• Iowa State University and University of Iowa. 2002. Iowa Concentrated Animal Feeding Operations Air Quality Study.  Iowa City: The University of Iowa College of Public Health.
• Jackson LL, Keeney D, Gilbert E. 2000. Swine manure management plans in North-Central Iowa: nutrient loading and policy implications. Journal of Soil and Water Conservation 55:205-212.
• Jacobson LD, Guo H, Schmidt DR, Nicolai RE. 2001. Influence of weather conditions on field evaluation of odor dispersions from animal production sites.  In: Proceedings of the Sixth International Livestock Environment Symposium, 21-23 May 2001.  Louisville, KY: American Society of Agricultural Engineers, 679-686.
• Jacobson LD, Moon R, Bicudo J, Janni K, Noll S, Shurson G, et al. 1999.  Generic environmental impact statement on animal agriculture:  Summary of the literature related to air quality and odor.  Prepared for the Minnesota Environmental Quality Board.  Minneapolis, MN: University of Minnesota, College of Agriculture, Food, and Environmental Sciences.  Available: http://www.mnplan.state.mn.us/pdf/1999/eqb/scoping/aircha.pdf    [accessed 26 September 2005].
• Jagielo PJ, Thorne PS, Watt JL, Frees KL, Quinn TJ, Schwartz DA. 1996. Grain dust and endotoxin inhalation challenges produce similar inflammatory responses in normal subjects. Chest 110:263-270.
• Jensen OM. 1982. Nitrate in drinking water and cancer in northern Jutland, Denmark, with special reference to stomach cancer.  Ecotoxicol Environ Saf 9:258-267.
• Kamrin MA. 1997. Pesticide Profiles: Toxicity, Environmental Impact, and Fate.CRC Press, Boca Raton (FL).
• Keddie AWC. 1980. Dispersion of odors.  In: Odour control: A concise guide.  (Valentine FHH, North AA, eds).  Stevenage, Hertfordshire, UK: Warren Springs Laboratory, Department of Industry.
• Kilpelaïnen M, Terho O, Helenius H, Koskenvuo M. 2000. Farm environment in childhood prevents the development of allergies. Clin Exp Allergy 30:201-208.
• Kimpbell-Dunn M, Bradshaw L, Slater T, Erkinjuntti-Pekkanen R, Fishwick D, Pearce N. 1999. Asthma and allergy in New Zealand farmers. Am J Ind Med 35:51-57.
• Kleiner AM, Rikoon JS, Seipel M.  Pigs, participation, and the democratic process: The impacts of proximity to large-scale swine operations on elements of social capital in Northern Missouri communities.  Paper presented at the Annual Meeting of the Rural Sociological Society, Washington DC, 2000.
• Kline JN, Cowden JD, Hunninghake GW, Schutte BC, Watt JL, Wohlford-Lenane CL, Powers LS, Jones MP, Schwartz DA 1999. Variable airway responsiveness to inhaled lipopolysaccharide. Am J Respir Crit Care Med 160:297-303.
• Kline JN, Waldschmidt TJ, Businga TR, Lemish JE, Weinstock JV, Thorne PS, Krieg AM. 1998. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol 160(6):2555-2559.
• Klintberg B, Berglund N, Lilja G, Wickman M, van Hage-Hamsten M. 2001. Fewer allergic respiratory disorders among farmers' children in a closed birth cohort from Sweden. Eur Respir J 17(6):1151-1157.
• Kogevinas M, Anto JM, Sunyer J, Tobia A, Kromhout H, Burney P. 1999. Occupational asthma in Europe and other industrialised areas: a population-based study. Lancet 353:1750-1754.
• Kolpin D. 2004. CAFO research by the USGS Toxics Substances Hydrology Program.  Presented at Environmental Health Impacts of CAFOs: Anticipating Hazards – Searching for Solutions, 29 March, 2004, Iowa City, IA: University of Iowa.
• Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT. 2002. Pharmaceuticals, hormones and other organic wastewater contaminants in U.S. streams, 1999-2000: A national reconnaissance.  Environ Sci Technol 36:1202-1211.
• Koppolu L, Schulte DD, Lin S, Rinkol MJ, Billesbach DP, Verma SB.  2002.  Comparison of AERMOD and STINK for dispersion modeling of odorous compounds.  Paper No. 024015.  ASAE Annual International Meeting, Chicago Illinois, July 2002.
• Kostraba JN, Gay EC, Rewers M, Hamman RF. 1992. Nitrate levels in community drinking waters and risk of IDDM: an ecological analysis.  Diabetes Care 15:1505-1508.
• Koziel JA, Spinhirne JP, Lloyd JD, Parker DB, Wright DW, Kuhrt FW. 2005.  Evaluation of sample recovery of malodorous livestock gases from air sampling bags, solid-phase microextraction fibers, Tenax TA sorbent tubes, and sampling canisters. J Air Waste Manag Assoc 55(8):1147-57.
• Kullman GJ, Thorne PS, Waldron PF, Marx JJ, Ault B, Lewis DM, Siegel PD, Olenchock SA, Merchant JA. 1998. Organic dust exposures from work in dairy barns. Am Indust Hyg Assoc J 59:403-413.
• Ladd AE, Edward B. 2002. Corporate Swine and Capitalist Pigs: A Decade of Environmental Injustice and Protest in North Carolina.  Social Justice, Vol. 29.
• Levy SB, Fitzgerald GB, Macone AB. 1976a. Changes in intestinal flora of farm personnel after introduction of a tetracycline-supplemented feed on a farm.  NEJM 295(11):583-588.
• Levy SB, Fitzgerald GB, Macone AB. 1976b. Spread of antibiotic-resistant plasmids from chicken to chicken and from chicken to man. Nature 260:40-42.
• Levy SB.  1998. The challenge of antibiotic resistance. Sci Amer 278(3):46-53.
• Li J, Dasgupta PK, Zhang G. 1999. Transversely illuminated liquid core wave guide based fluorescence detection, Fluorometric flow injection determination of aqueous ammonium/ammonia.  Talanta 50:617-623.
• Li JD, Bundy DS, Hoff SJ, Liu Q. 1994. Field odor measurement and applications of Gaussian plume model.  ASAE Paper No. 944054.  St. Joseph, MI: American Society of Agricultural Engineers.
• Liu AH, Leung YM. 2000. Modulating the early allergic response with endotoxin. Clin Exp Allergy 30:1535-1539.
• MacCannell D. 1988. Industrial agriculture and rural community degradation.  In: Agriculture and community change in the U.S.: The Congressional research reports (Swanson LE, ed). Boulder, CO: Westview Press, 15-75.
• Mallin MA. 2000. Impacts of industrial-scale swine and poultry production on rivers and estuaries.  Am Sci 88:26-37.
• Mallin, MA, Burkholder JM, Shank GC, McIver MR, Glasgow HB, Springer J, et al. 1997.  Comparative impacts of effluent from poultry and swine waste holding lagoon spills on receiving rivers and tidal creeks.  J Environ Qual 26:1622-1631.
• Martinez FD, Holt PG. 1999. Role of microbial burden in aetiology of allergy and asthma. Lancet 354:12-15.
• McCulloch RB, Shendrikar AD.  2000. Concurrent atmospheric ammonia measurements using citric-acid-coated diffusion denuders and a chemiluminescence analyzer.  Atmospheric Environment 34:4957-4958.
• McLachlan JA, Korach KS. 1995. Symposium on Estrogens in the Environment, III.  Environ Health Perspec 103:3-4.
• Melbostad E, Eduard W, Magnus P. 1998. Determinants of asthma in a farming population. Scand J Work Environ Health 24:262-269.
• Mennen MG, Van Elzakker BG, Van Putten EM, Uiterwijk JW, Regts TA, Van Hellemond J, et al.  1996. Evaluation of automatic ammonia monitors for application in an air quality monitoring network.  Atmospheric Environment 30(19):3239-3256.
• Merchant JA, Naleway AL, Svendsen ER, Kelly KM, Burmeister LF, Stromquist AM, Taylor CD, Thorne PS, Reynolds SJ, Sanderson WT, Chrischilles EA.  2005. Asthma and farm exposures in a cohort of rural Iowa children. Environ Health Perspect 113(3):350-356.
• Meyer MT. 2004. Use and Environmental Occurrence of Veterinary Pharmaceuticals in the United States. In: Pharmaceuticals in the environment:  Sources, fate, effects, and risks (Kummerer K, ed). Berlin, Heidelberg, New York: Springer-Verlag, 155-164.
• Michel O, Ginanni R, Duchateau J, Vertongen F, Le Bon B, Sergeysels R. 1991. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy 21:441-448.
• Michel O, Kips J, Duchateau J, Vertongen F, Robert L, Collet H, Pauwels R, Sergysels R. 1996. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 154:1641-1646.
• Michel O, Nagy AM, Schroeven M, Duchateau J, Nève J, Fondu P, Sergysels R. 1997. Dose-response relationship to inhaled endotoxin in normal subjects. Am J Respir Crit Care Med 156:1157-1164.
• Mirabelli MC. 2005. Exposure to airborne emissions from confined swine feeding operations as a trigger of childhood respiratory symptoms.   Doctoral Dissertation, Department of Epidemiology, The University of North Carolina at Chapel Hill.
• MMWR (Morbidity and Mortality Weekly Report). 1996. Spontaneous abortions possibly related to ingestion of nitrate-contaminated well water - LaGrange County, Indiana, 1991-1994.  MMWR 45:569-572.
• Mølbak K, Baggesen DL, Aarestrup FM, Ebbesen JM, Engberg J, Frydendahl K, Gerner-Smidt P, Petersen AM, Wegener HC.1999. An outbreak of multidrug-resistant, quinolone-resistant Salmonella enterica serotype Typhimurium DT104.  NEJM 341:1420-1425.
• Morales-Suarez-Varela M, Llopis-Gonzales A, Tejerizo-Perez ML, Ferrandiz Ferragud J. 1993. Concentration of nitrates in drinking water and its relationship with bladder cancer.  J Environ Pathol Toxicol Oncol 12:229-236.
• Morales-Suarez-Varela MM, Llopis-Gonzalez A, Tejerizo-Perez ML. 1995. Impact of nitrates in drinking water on cancer mortality in Valencia, Spain.  Eur J Epidemiol 11:15-21.
• MPCA (Minnesota Pollution Control Agency). 2003. Draft environmental impact statement on the Hancock Pro Pork Feedlot Project, Stevens and Pope Counties. Minnesota Pollution Control Agency, St. Paul MN. 2003. Available: http://www.pca.state.mn.us/news/eaw/hancock-eis.pdf [accessed 26 September 2005].
• Mueller BA, Newton, K, Holly EA, Preston-Martin S.  2001. Residential water source and the risk of childhood brain tumors.  Environ Health Perspec 109:551-556.
• NAS (National Academy of Sciences).  2003. Microbial Threats to Health: Emergence, Detection and Response (Smolinski MS, Hamburg MA, and Lederberg J, eds). Committee on Emerging Microbial Threats to Health in the 21st Century, Board on Global Health.  Washington, DC: Institute of Medicine of the National Academies, National Academies Press.
• National Research Council, Ad Hoc Committee on Air Emissions from Animal Feeding Operations, Committee on Animal Nutrition. 2003.  Air emissions from animal feeding operations: Current knowledge, future needs.Washington, DC: National Academy Press.
• National Research Council, Committee on Haze in National Parks and Wilderness Areas, Board on Environmental Studies and Toxicology, Commission on Geosciences, Environment, and Resources. 1993. Protecting visibility in national parks and wilderness areas.  Washington, DC: National Academy Press.
• Nature (Editorial). 2005. On a wing and a prayer. Nature 435(7041):385-386.
• Neijari C, Tessier JF, Letenneur L, Dartigues JF, Barberger-Gateau P, Salamon R. 1996. Prevalence of self-reported asthma symptoms in a French elderly sample. Respir Med 90:401-408.
• Omland O, Sigsgaard T, Hjort C, Pedersen OF, Miller MR. 1999. Lung status in young Danish rurals: the effect of farming exposure on asthma-like symptoms and lung function. Eur Respir J 13:31-37.
• Otto D, Lawrence J. The Iowa pork industry 2000: Trends and economic importance, ISU Economics Working Paper. Available:  http://www.econ.iastate.edu/outreach [accessed 10 October 2005].
• Palmquist RB, Roka FM, Vukina T. 1997. Hog operations, environmental effects and residential property values.  Land Economics 73:114-124.
• Parbst KE, Keener KM, Heber AJ, Ni JQ.  2000. Comparison between low-end discrete and high-end continuous measurements of air quality in swine buildings.  Applied Engineering in Agriculture 16(6):693-699. 
• Paton NI, Leo YS, Zaki SR, Auchus AP, Lee KE, Ling AE, Chew SK, Ang B, Rollin PE,Umapathi T, Sng I, Lee CC, Lim E, Ksiazek TG. 1999. Outbreak of Nipah-virus infection among abattoir workers in Singapore.  Lancet 354(9186):1253-1256.
• Peterson RD, Wicklund PE, Good RA. 1964. Endotoxin activity of a house dust extract. Allergy 35:134-142.
• Portengen L, Preller L, Tielen M, Doekes G, Heederik D. 2005. Endotoxin exposure and atopic sensitization in adult pig farmers. J All Clin Immunol 115(4):797-802.
• Portengen L, Sigsgaard T, Omland O, Hjort C, Heederik D, Doekes G. 2002. Low prevalence of atopy in young Danish farmers and farming students born and raised on a farm. Clin Exp Allergy 32(2):247-53.
• Powers WJ, Bundy DS, van Kempen T, Sutton A, Hoff SJ. 2000. Objective measurement of odors using gas chromatography/mass spectrometry and electronic nose technologies.  Presented at the Second International Conference on Air Pollution from Agricultural Operation 9-11 October, 2000, Des Moines, Iowa.
• Preller L, Heederik D, Boleij JS, Vogelzang PF, Tielen MJ.  1995. Lung function and chronic respiratory symptoms of pig farmers: focus on exposure to endotoxins and ammonia and use of disinfectants.  Occup Environ Med 52(10):654-660.
• Pushkarsky MB, Webber ME, Baghdassarian O, Narasimhan LR, Patel CKN. 2002. Trends in laser sources, spectroscopic techniques and their applications to trace gas detection.  Applied Physics B Special Issue 75(2-3):391-396.
• Quinn AD, Wilson M, Reynolds AM, Couling SB, Hoxey RP. 2001.  Modeling the dispersion of aerial pollutants from agricultural buildings – an evaluation of computational fluid dynamics (CFD).  Computers and Electronics in Agriculture 30:219-235.
• Rademacher JJ, Young TB, Kanarek MS. 1992. Gastric cancer mortality and nitrate levels in Wisconsin drinking water.  Arch Environ Health 47:292-294.
• Radon K, Schulze A, van Strien R, Ehrenstein V, Praml G, Nowak D. 2005. [Respiratory health and allergy among young adults from rural areas of Lower Saxony]: 50th Annual Meeting of the German Society for Medical Informatics, Biometrics and Epidemiology.  Available at: http://www.egms.de/en/meetings/gmds2005/05gmds237.shtml. [accessed 7 November 2005].
• Rao PV, Gupta N, Bhaskar AS, Jayaraj R. 2002. Toxins and bioactive compounds from cyanobacteria and their implications on human health.  J Env Biol 23:215-224.
• Rapala J, Lahti K, Rasanen LA, Esala AL, Niemela SI, Sivonen K. 2002. Endotoxins associated with cyanobacteria and their removal during drinking water treatment.  Water Research 36:2627-2635.
• Rege MA, Tock RW. 1996. Estimation of point-source emissions of hydrogen sulfide and ammonia using a modified Pasquill-Gifford approach.  Atmospheric Environment 30(18):3181-3195.
• Reynolds S, Donham K, Stooksberry J, Thorne PS, Subramanian P, Thu K, Whitten P.  1997. Air quality assessments in the vicinity of swine production facilities.  Agricultural Health and Safety: Recent Advances 4:57-45.
• Reynolds SJ, Donham KJ, Whitten P, Merchant JA, Burmeister LF, Popendorf WJ. 1996. Longitudinal evaluation of dose-response relationships for environmental exposures and pulmonary function in swine production workers.  Am J Ind Med 29:33-40.
• Riedler J, Eder W, Oberfeld G, Schreuer M. 2000. Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clin Exp Allergy 30:194-200.
• Ryan VD, Terry Al, Besser TL. 1995. Rural communities, structural capacity, and the importance of social capital.  Presented at the Rural Sociological Society Meetings, Washington, DC, August 17-20, 1995.
• Rylander R, Donham K, Hjort C, Brouwer R, Heederik D. 1989. Effects of exposure to dust in swine confinement buildings – a working group report.  Scand J Work Environ Health 15:309-312.
• Rylander R. 1997. Evaluation of the risks of endotoxin exposure. Int J Occup Environ Health 3 (suppl 1):S32-36.
• Sandström T, Bjermer L, Rylander R. 1992. Lipopolysaccaride (LPS) inhalation in healthy subjects increases neutrophils, lymphocytes and fibronectin levels in bronchoalveolar lavage fluid. Eur Respir J 5:992-996.
• Schenker M, Christiani D, Cormier Y, Dimich-Ward H, Doekes G, Dosman J, et al. 1998. Respiratory Health Hazards in Agriculture. Am J Resp Crit Care Med Suppl 158(Part 2):S1-S76.
• Schiffman S, Walker J, Dalton P, Lorig T, Raymer J, Shusterman D, Williams C. 2000. Potential health effects of odor from animal operations, wastewater treatment, and recycling of byproducts.  J Agromed 7:7-81.
• Schiffman SS, Miller EA, Suggs MS, Graham BG. 1995. The effect of environmental odors emanating from commercial swine operations on the mood of nearby residents.  Brain Res Bull 37:369-375.
• Schwartz DA, Landas SK, Lassise DL, Burmeister LF, Hunninghake GW, Merchant JA. 1992. Airway injury in swine confinement workers.  Ann Intern Med 116:630-635.
• Seffner W. 1995. Natural water contents and endemic goiter. Zantralblatt fur Hygiene und Umweltmedizin 196:381-398.
• Sengelov G, Agerso Y, Halling-Sorensen B, Baloda SB, Andersen JS, Jensen LB. 2003. Bacterial antibiotic resistance levels in Danish farmland as a result of treatment with pig manure slurry. Environment International 28:587-595.
• Sharpe RR, Harper LA. 1997. Ammonia and nitrous oxide emissions from sprinkler irrigation applications of swine effluent.  J Environ Qual 26:1703-1706. 
• Sharpley A, Moyer B.  2000. Phosphorus forms in manure and compost and their release during simulated rainfall.  J Environ Qual 29:1462-1469.
• Sheppard SC. 2002. Three approaches to define the ecotoxicity threshold for atmospheric ammonia.  Can J Soil Sci 82:341-354.
• Shirakawa T, Enomoto T, Shimazu S, Hopkin JM. 1997. The inverse association between tuberculin responses and atopic disorder. Science 275(5296):77-79.
• Shusterman D. 1992. Critical review: the health significance of environmental odor pollution.  Arch Environ Health 47:76-87.
• Singles R, Sutton MA, Weston KJ. 1998. A multi-layer model to describe the atmospheric transport and deposition of ammonia in Great Britain.  Atmospheric Environment 32(3):393-399.
• Smith RJ, Watts PJ. 1994. Determination of odour emission rates from cattle feedlots: Part 2, evaluation of two wind tunnels of different size.  J of Agric Eng Res 58:231-240.
• Smith RJ. 1993. Dispersion of odours from ground level agricultural sources.  J Agric Eng Res 54:187-200.
• Soto AM, Calabro JM, Prechtl NV, Yau AY, Orlando EF, Daxenberger A, Kolok AS, Guillette LJ Jr, le Bizec B, Lange IG, Sonnenschein C. 2004. Androgenic and estrogenic activity in water bodies receiving cattle feedlot effluent in eastern Nebraska, USA. Environ Health Perspec 112:346-352.
• State of Colorado. 1999.  Colorado Regulation #2: Odor emission.  Denver, CO: Air Quality Commission, Colorado Department of Public Health and Environment.    Available: http://www.cdphe.state.co.us/op/regs/airregs/100104aqccodoremission.pdf [accessed 26 September 2005].
• State of Minnesota. 2003. Measurement Methodology for Hydrogen Sulfide.  Minnesota Rule 7009.0060. Saint Paul, MN.  Available: http://www.revisor.leg.state.mn.us/arule/7009/0060.html   [accessed 26 September 2005].
• State of Missouri. 2003. Restriction of Emission of Odors.  Missouri 10 CSR 10-4.070.  Available: http://www.sos.state.mo.us/adrules/csr/current/10csr/10c10-4.pdf  [accessed 26 September 2005].
• State of Missouri. 2004. Reference Methods.  In: Air Quality Standards, Definition, Sampling, and Reference Methods and Air Pollution Control Regulations for the Entire State of Missouri.  Missouri Rule 10 CSR 10-6.040(5).  Available: http://www.sos.state.mo.us/adrules/csr/current/10csr/10c10-6a.pdf [accessed 26 September 2005].
• State of Nebraska. 2002.  Nebraska Air Quality Regulations, Title 129, Chapter 4 Ambient Air Quality Standards - Revised 4-01-2002; Available: http://www.deq.state.ne.us [accessed 26 September 2005].
• Steindorf K, Schlehofer B, Becher H, Hornig G, Wahrendorf J.  1994. Nitrate in drinking water: a case-control study on primary brain tumours with an embedded drinking water survey in Germany.  Int J Epidemiol 23:451-457.
• Stone KC, Hunt PG, Coffey SW, Matheny TA. 1995. Water quality status of A USDA water quality demonstration project in the Eastern Coastal Plain.  J Soil Wat Conserv 50:567-571.
• Stone RB.  Rural Iowans can again sue hog facilities.  Iowa Civil Liberties Union.  June 16, 2004.  Available: http://www.iowaclu.org/news.asp?ID=13  [accessed 26 September 2005].
• Subramanian P, Reynolds S, Thorne PS, Donham K, Stookesberry J, Thu K. 1996. Assessment of airborne ammonia in a swine environment by the fluorimetric enzyme method.  Intern J Environ Anal Chem 64:301-312.
• SVARM 2003, Swedish Veterinary Antimicrobial Resistance Monitoring.  The National Veterinary Institute (SVA), Uppsala, Sweden, 2003.  Available: www.sva.se/  [accessed 26 September 2005].
• Thorne PS, Kulhankova K, Yin M, Cohn R, Arbes Jr. SJ, Zeldin DC. 2005. Endotoxin Exposure is a Risk Factor for Asthma: The National Survey of Endotoxin in U.S. Housing. Am J Respir Crit Care Med. 172:1371-1377, 2005. Doi:10.1164/rccm.200505-758OC
• Thorne PS, Kulhankova K, Yin M, Cohn R, Arbes S, Zeldin DC. 2003. Endotoxin in house dust is associated with asthma but not allergy. Am J Resp Crit Care Med, 167(8): A470.
• Thouez J-P, Beauchamp Y, Simard A. 1981. Cancer and the physicochemical quality of drinking water in Quebec.  Soc Sci Med 15D:213-223.
• Thu K, Donham K, Ziegenhorn R, Reynolds S, Thorne PS, Subramanian P, Whitten P, Stookesberry J. A control study of the physical and mental health of residents living near a large-scale swine operation. J Agric Safety Health 3(1):13-26, 1997.
• Thu K, Donham K. 1996. Understanding the Impacts of Large-Scale Swine Production.  Proceedings from an Interdisciplinary Scientific Workshop, Des Moines, IA 29-30 June, 1995.  Iowa City, IA: University of Iowa Environmental Health Sciences Research Center.
• Thu K, ed.  1996.  Understanding the Impacts of Large-Scale Swine Production: Proceedings from an Interdisciplinary Scientific Workshop. Iowa City, Iowa: The University of Iowa.
• Thu KM, Durrenberger P, eds.  1998. Pigs profits and rural communities.  Albany, NY: State University of New York Press. 
• Thu, K. 2002 Public Health Concerns for Neighbors of Large-Scale Swine Production.” Journal of Agricultural Safety and Health 8(2):175-184.
• Toda K, Dasgupta PK, Li J, Tarver GA, Zarus GM. 2001. Fluorometric field instrument for continuous measurement of atmospheric hydrogen sulfide.  Anal Chem 73:5716-5724.
• Toren K, Horte L-G, Jarvholm B. 1991. Occupation and smoking adjusted mortality due to asthma among Swedish men. Br J Ind Med 48:323-326.
• U.S. EPA (Environmental Protection Agency). 1995. User's guide for the industrial source complex (ISC3) dispersion models.  Research Triangle Park, NC:U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards Emissions, Monitoring, Analysis Division.  Available: http://www.epa.gov/scram001/userg/regmod/isc3v2.pdf [accessed 26 September 2005].
• U.S. EPA (Environmental Protection Agency). 2003a. Air trends report.  EPA Publication Number 454/K-03-001, EPA (U.S. Environmental Protection Agency).  Technology Transfer Network Ambient Monitoring Technology Information Center.  Available: http://www.epa.gov/ttn/amtic/   [accessed 26 September 2005].
• U.S. EPA (Environmental Protection Agency). 2003b. Revision to the guideline on air quality models: Adoption of a preferred long range transport model and other revisions; Final Rule. 40 CFR Part 51.  Available: http://www.epa.gov/ttn/scram/guidance/guide/appw_03.pdf    [accessed 26 September 2005].
• U.S. EPA. 1998. Environmental Impacts of Animal Feeding Operations.  Washington, DC: Office of Water, Standards and Applied Sciences Division, U.S. EPA.  Available:  http://www.epa.gov/ostwater/guide/feedlots/envimpct.pdf  [accessed 26 September 2005].
• UNEP/RIVM.  United Nations Environment Program/Rijksinstituut voor Volksgezondheid en Milieu.1999. Bouwman AF and Van Vuuren DP.  Global assessment of acidification and eutrophication of natural ecosystems.  UNEP/DELA&EW/TR-996 and RIVM 402001012.
• Union of Concerned Scientists. 2001. Hogging It!  Estimates of antimicrobial abuse in livestock (Mellon M, Benbrook C, Benbrook KL, eds).  Cambridge, MA: UCS Publications.
• Van Loon AJM, Botterweck AAM, Goldbohm RA, Brants HAM, van Klaveren JD, van den Brandt PA. 1998. Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study.  Br J Cancer 7:129-135.
• Vogelzang PF, van der Gulden JW, Folgering H, Kolk JJ, Heederik D, Preller L, Tielen MJ, van Schayck CP. 1998. Endotoxin exposure as a major determinant of lung function decline in pig farmers. Am J Resp Crit Care Med 157:15-18.
• Vogelzang PF, van der Gulden JW, Tielen MJ, Folgering H, van Schayck CP. 1999. Health-based selection for asthma, but not for chronic bronchitis, in pig farmers: an evidence-based hypothesis. Eur Resp J 13:187-189.
• Von Eherenstein OS, Von Mutius E, Illi S, Baumann L, Böhm O, Von Kries R. 2000. Reduced risk of hay fever and asthma among children of farmers. Clin Exp Allergy 30:187-193.
• Von Essen S. Romberger D. 2003. The respiratory inflammatory response to the swine confinement building environment: the adaptation to respiratory exposures in the chronically exposed worker. J Agric Safety Health. 9(3):185-196.
• von Mutius E, Braun-Fahrländer C, Schierl R, Riedler J, Ehlermann S, Maisch S, Waser M, Nowak D. 2000. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 30:1230-1234.
• Ward MH, Cantor KP, Riley D, Merkle S, Lynch CF. 2003. Nitrate in public water supplies and risk of bladder cancer.  Epidemiology 14:183-190.
• Ward MH, Mark SD, Cantor KP, Weisenburger DD, Correa-Villasenore A, Zahm SH. 1996. Drinking water and the risk of non-Hodgkin's lymphoma.  Epidemiology 7:465-471.
• Watson JG, Chow JC, Moosmüller H, Green M, Frank N, Pitchford M. 1998. Guidance for using continuous monitors in PM2.5 monitoring networks.  Office of Air Quality Planning and Standards.  U.S. Environmental Protection Agency.  Available: http://www.epa.gov/ttnamti1/files/ambient/pm25/r-98-012.pdf [accessed September 26, 2005].
• Webb J, Archer JR. 1994. Pollution of soils and watercourses by wastes from livestock production systems.  In: Pollution in Livestock Production Systems (Dewi IA, Axford RFE, Marai A, Omed HM, eds).Oxfordshire, UK: CABI Publishing, 189-204.
• Webb S, Ternes T, Gibert M, Olejniczak K. 2003. Indirect human exposure to pharmaceuticals via drinking water.  Toxicology Letters 142:157-167.
• Webster R, Hulse D.  2005. Controlling avian flu at the source.  Nature 435:415-416.
• Wegener HC.  2003. Antibiotics in animal feed and their role in resistance development. Curr Opin Microbiol 6(5):439-445.
• Weisenburger D. 1993. Potential health consequences of ground-water contamination of nitrates in Nebraska.  Nebr Med J 78:7-10.
• Westerman PW, Huffman RL, Feng JS. 1995. Swine-lagoon seepage in sandy soil. Transaction of the ASAE 38(6):1749-1760.
• Weyer P, Riley D. 2001. Endocrine disruptors and pharmaceuticals in drinking water.  Denver, CO: AWWA Research Foundation and the American Water Works Association.
• Weyer PJ, Cerhan JR, Kross BC, Hallberg GR, Kantamneni J, Breuer G, Jones MP, Zheng W, Lynch CF. 2001. Municipal drinking water nitrate level and cancer risk in older women: the Iowa Women's Health Study.  Epidemiology 11:327-338.
• White DG, Zhao S, Sudler R, Ayers S, Friedman S, Chen S, McDermott PF, McDermott S, Wagner DD, Meng J.  2001. The Isolation of Antibiotic-Resistant Salmonella from Retail Ground Meats.  NEJM  345:1147-1154.
• WHO (World Health Organization). 2004. Microbial Aspects. In: Guidelines for Drinking Water Quality.  Volume 1, Third Edition.  Geneva, Switzerland: World Health Organization, 121-143.
• WHO. 2003.   Impacts of Antimicrobial Growth Promoter Termination in Denmark: World Health Organization International Review Panel’s Evaluation of the Termination of the Use of Antimicrobial Growth Promoters in Denmark. Foulum, Denmark, Nov 6-8, 2002.  WHO/CDS/CPE/ZFK/2003.1
• WHO. 2004. Avian Influenza A (H5N1) – update 31. Available: http://www.who.int/csr/don/2004_03_02/en/. [accessed 26 September 2005].
• Wilson S, Howell F, Wing S, Sobsey M.   2002.  Environmental injustice and the Mississippi hog industry. Environmental Health Perspectives, 110 (Supplement 2):195-201.
• Wing S, Cole D. 2000. Environmental Injustice in North Carolina’s Hog Industry. Environmental Health Perspectives 108(2):225-231.
• Wing S, Freedman S, Band L. 2002. The potential impact of flooding on confined animal feeding operations in eastern North Carolina.  Environ Health Perspect 110:387-391.
• Wing S, Wolf S. 2000. Intensive livestock operations, health, and quality of life among eastern North Carolina residents.  Environmental Health Persp 108:233-238.
• Wollenberger L, Halling-Sorensen B, Kusk KO. 2000. Acute and chronic toxicity of veterinary antibiotics to Daphnia magna. Chemosphere 40:723-730.
• World Health Organization (WHO). 1946. Preamble to the Constitution of the World Health Organization as adopted by the International Health Conference, New York, 19-22 June, 1946; signed on 22 July 1946 by the representatives of 61 States (Official Records of the World Health Organization, no. 2, p. 100) and entered into force on 7 April 1948.
• Wright W, Flora CB, Kremer KS, Goudy W, Hinrichs C, Lasley P, Maney A, Kroma M, Brown H, Pigg K, Durgan B, Coleman J, Elias Morse D.  2001. Technical work paper on social and community impacts.  Prepared for the Generic Environmental Impact Statement on Animal Agriculture and the Minnesota Environmental Quality Board.
• Yang C-Y, Cheng M-F, Tsai S-S, Hsieh Y-L. 1998. Calcium, magnesium, and nitrate in drinking water and gastric cancer mortality.  Jpn J Cancer Res 89:124-130.
• Yazdanbakhsh M, Kremsner PG, van Ree R. 2002. Allergy, parasites, and the hygiene hypothesis. Science 296:490-494.
• Zahn JA, Anhalt J, Boyd E.  2001.  Evidence for transfer of tylosin and tylosin-resistant bacteria in air from swine production facilities using sub-therapeutic concentrations of tylan in feed.  J Anim Sci 79:189.
• Zahn JA, Hatfield JL, Do YS. 1997. Characterization of volatile organic emissions and wastes from a swine production facility.  J Environ Qual 26:1687-1696.
• Zhu JL, Jacobson D, Schmidt R, Nicolai. 2000. Evaluation of INPUFF-2 model for predicting downwind odors from animal production facilities.  App Eng in Agric 16(2): 159-164.
• Wollenberger L, Halling-Sorensen B, Kusk KO. 2000. Acute and chronic toxicity of veterinary antibiotics to Daphnia magna. Chemosphere 40:723-730.
• World Health Organization (WHO). 1946. Preamble to the Constitution of the World Health Organization as adopted by the International Health Conference, New York, 19-22 June, 1946; signed on 22 July 1946 by the representatives of 61 States (Official Records of the World Health Organization, no. 2, p. 100) and entered into force on 7 April 1948.
• Wright W, Flora CB, Kremer KS, Goudy W, Hinrichs C, Lasley P, Maney A, Kroma M, Brown H, Pigg K, Durgan B, Coleman J, Elias Morse D.  2001. Technical work paper on social and community impacts.  Prepared for the Generic Environmental Impact Statement on Animal Agriculture and the Minnesota Environmental Quality Board.
• Yang C-Y, Cheng M-F, Tsai S-S, Hsieh Y-L. 1998. Calcium, magnesium, and nitrate in drinking water and gastric cancer mortality.  Jpn J Cancer Res 89:124-130.
• Yazdanbakhsh M, Kremsner PG, van Ree R. 2002. Allergy, parasites, and the hygiene hypothesis. Science 296:490-494.
• Zahn JA, Anhalt J, Boyd E.  2001.  Evidence for transfer of tylosin and tylosin-resistant bacteria in air from swine production facilities using sub-therapeutic concentrations of tylan in feed.  J Anim Sci 79:189.
• Zahn JA, Hatfield JL, Do YS. 1997. Characterization of volatile organic emissions and wastes from a swine production facility.  J Environ Qual 26:1687-1696.
• Zhu JL, Jacobson D, Schmidt R, Nicolai. 2000. Evaluation of INPUFF-2 model for predicting downwind odors from animal production facilities.  App Eng in Agric 16(2): 159-164.