EHSRC Investigator Detail
| Gail A. Bishop, Ph.D. | |
| Carver College of Medicine Distinguished Professor of Microbiology and Internal Medicine | |
| Email: gail-bishop@uiowa.edu | |
| Phone: (319) 335-7945 | |
| Bishop Lab Website: http://www.medicine.uiowa.edu/bishoplab/ | |
| EHSRC Role(s): | Member, Inflammation and Innate Immunity Research Cluster |
Dr. Bishop's laboratory is interested in the molecular mechanisms which underlie the processes of B lymphocyte activation in normal immunity, autoimmunity, and malignancy. They are particularly interested in how signals delivered via B cell transmembrane molecules regulate these events, with a particular area of focus on antigen-specific, T cell-B cell interactions.
Selected Publications
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Haxhinasto, S.A. and Bishop, G.A. Synergistic B cell activation by CD40 and the B cell antigen receptor: Role of BCR-mediated kinase activation and TRAF regulation. J. Biol. Chem.279:2575-2582, 2004.
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Xie, P., Hostager, B.S. and Bishop, G.A. Requirement for TRAF3 in signaling by the EBV-encoded oncoprotein LMP1, but not CD40, in B lymphocytes. J. Exp. Med. 199:661-671, 2004.
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Stunz, L.L., Busch, L.K., Munroe, M.E., Sigmund, C.D., Tygrett, L.T., Waldschmidt, T.J., and Bishop, G.A. Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture. Immunity 21:255-266, 2004.
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Xie, P. and Bishop, G.A. Roles of TRAF3 in signaling by CTAR1 and CTAR2 of the EBV-encoded oncoprotein, LMP1. J. Immunol. 173:5546-5555, 2004.
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Munroe, M.E. and Bishop, G.A. Role of TRAF2 in distinct and overlapping CD40 and TNFR2/CD120b-mediated B lymphocyte activation. J. Biol. Chem. 279: 53222-53231, 2004.
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Mukundan, L., Bishop, G.A., Head, K.Z., Zhang, L., Wahl, L.M. and Suttles, J. TRAF6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages. J. Immunol. 174:1081-1090, 2005.
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Moore, C.R. and Bishop, G.A. Differential regulation of CD40-mediated TRAF degradation in B lymphocytes. J. Immunol. 175:3780-3789, 2005.
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Wu, S., Xie, P., Welsh, K., Li, C., Ni, C., Zhu, X., Reed, J.C., Satterthwait, A.C., Bishop, G.A. and Ely, K.R. LMP1 protein from EBV is a structural decoy in B lymphocytes for binding to TRAF3. J. Biol. Chem. 280:33620-33626, 2005.
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Andrade, R.M., Wessendarp, M., Portillo, J.C., Yang, J., Gomez, F.J., Durbin, J.E., Bishop, G.A. and Subuaste, C.S. TRAF6-dependent CD40 signaling primes macrophages to acquire anti-microbial activity in response to TNF-a . J. Immunol. 175:6015-6021, 2005.