| John F. Engelhardt, PhD |
| Professor of Anatomy |
| Email: john-engelhardt@uiowa.edu |
| Phone: (319) 335-9855 |
| EHSRC Role(s): |
Member, Inflammation and Innate Immunity Research Cluster |
Dr. Engelhardt's research focuses on the development of gene therapies for inherited and environmentally induced diseases. Included are two major research areas: 1) The study of lung molecular and cellular biology as it relates to the pathogenesis and treatment of cystic fibrosis (CF) lung disease and 2) Molecular mechanism of redox-mediated environmental injuries such as ischemia/reperfusion injury and sepsis and the development of molecular therapies for these disorders.
Recent Publications
-
Fox LE, Green D, Yan Z, Engelhardt JF, Wu CF. Screen for dominant behavioral mutations caused by genomic insertion of P-element transposons in Drosophila: an examination of the integration of viral vector sequences. J Neurogenet. 2007 Jan-Jun;21(1-2):31-43.
-
Driskell RR, Goodheart M, Neff T, Liu X, Luo M, Moothart C, Sigmund CD, Hosokawa R, Chai Y, Engelhardt JF. Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev Biol. 2007 May 1;305(1):90-102. Epub 2007 Feb 7.
-
Yan Z, Lei-Butters DC, Zhang Y, Zak R, Engelhardt JF. Hybrid adeno-associated virus bearing nonhomologous inverted terminal repeats enhances dual-vector reconstruction of minigenes in vivo. Hum Gene Ther. 2007 Jan;18(1):81-7.
-
Liu X, Driskell RR, Engelhardt JF. Stem cells in the lung. Methods Enzymol. 2006;419:285-321.
-
Liu X, Luo M, Zhang L, Ding W, Yan Z, Engelhardt JF. Bioelectric properties of chloride channels in human, pig, ferret, and mouse airway epithelia. Am J Respir Cell Mol Biol. 2007 Mar;36(3):313-23. Epub 2006 Sep 28.
-
Dajani R, Sanlioglu S, Zhang Y, Li Q, Monick MM, Lazartigues E, Eggleston T, Davisson RL, Hunninghake GW, Engelhardt JF. Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS. Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G242-52. Epub 2006 Aug 24.
|
